Maternal Caffeine Administration and Cerebral Oxygenation in Near-Term Fetal Sheep

The authors test the null hypothesis that maternal caffeine administration will not significantly alter fetal cerebral oxygenation. The authors measured fetal arterial blood gases, cortical tissue O2 tension (tPO2), sagittal sinus blood gases, and laser Doppler cerebral blood flow in response to a 3...

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Bibliographic Details
Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2007-09, Vol.14 (6), p.588-594
Main Authors: Tomimatsu, Takuji, Lee, Stephen J., Pereyra Peña, Jorge, Ross, Jonathon M., Lang, Jordan A., Longo, Lawrence D.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Flow Velocity - drug effects
Brain - drug effects
Brain - embryology
Brain - metabolism
Caffeine - administration & dosage
Caffeine - pharmacology
Central Nervous System Stimulants - administration & dosage
Central Nervous System Stimulants - pharmacology
Cerebrovascular Circulation - drug effects
Dose-Response Relationship, Drug
Female
Fetal Blood - metabolism
Gestational Age
Gynecology. Andrology. Obstetrics
Infusions, Intravenous
Maternal-Fetal Exchange
Medical sciences
Oxygen - blood
Oxygen - metabolism
Oxygen Consumption - drug effects
Pregnancy
Sheep
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Summary:The authors test the null hypothesis that maternal caffeine administration will not significantly alter fetal cerebral oxygenation. The authors measured fetal arterial blood gases, cortical tissue O2 tension (tPO2), sagittal sinus blood gases, and laser Doppler cerebral blood flow in response to a 30-minute caffeine infusion (400 mg intravenously) into 7 near-term pregnant ewes, and they calculated fractional O2 extraction and relative cerebral metabolic rate for O2 (CMRO2). Following maternal caffeine infusion, both fetal cortical tPO2 and sagittal sinus (HbO2) decreased significantly, from 10.7 ± 0.9 to 6.8 ± 1.1 Torr and from 46% ± 2% to 37% ± 6%, respectively. This was associated with significant 20% to 30% increases in fractional O2 extraction and CMRO 2. Fetal arterial blood gas values did not change significantly. In conclusion, maternal caffeine administration significantly decreases cerebral oxygenation without affecting systemic oxygenation in fetal sheep. The authors speculate that for a fetus that may be otherwise compromised, this increase in CMRO2 with decreased cortical tPO2 could present a problem.
ISSN:1933-7191
1933-7205
DOI:10.1177/1933719107307717