Hyperhomocysteinaemia as a Risk Factor for Deep-vein Thrombosis

Several studies have shown a relation between hyperhomocysteinaemia and vascular disease. To assess the risk of deep-vein thrombosis (DVT) associated with hyperhomocysteinaemia, we studied plasma homocysteine levels in patients with deep-vein thrombosis and in normal control subjects. We measured pl...

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Bibliographic Details
Published in:European journal of vascular and endovascular surgery 2005-09, Vol.30 (3), p.315-318
Main Authors: Ünlü, Y., Keleş, S., Becit, N., Koçoğulları, C.U., Koçak, H., Bakan, E.
Format: Article
Language:English
Subjects:
Adult
Aged
Deep-vein thrombosis
Female
Homocysteine - blood
Humans
Hyperhomocysteinaemia
Hyperhomocysteinemia - blood
Hyperhomocysteinemia - complications
Male
Middle Aged
Retrospective Studies
Risk factor
Risk Factors
Venous Thrombosis - blood
Venous Thrombosis - etiology
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Summary:Several studies have shown a relation between hyperhomocysteinaemia and vascular disease. To assess the risk of deep-vein thrombosis (DVT) associated with hyperhomocysteinaemia, we studied plasma homocysteine levels in patients with deep-vein thrombosis and in normal control subjects. We measured plasma homocysteine levels in 48 patients with deep-vein thrombosis and in 33 healthy controls matched to the patients according to age and sex. Plasma homocysteine levels were measured with high performance liquid chromatography and fluorescence detection. Hyperhomocysteinaemia was defined as a plasma homocysteine level about 15μmol/L in both groups. The diagnosis of all patients with deep-vein thrombosis (n=48) was verified by Doppler ultrasonography. Plasma homocysteine levels were found to be increased in the deep-vein thrombosis group compared the control group (p
ISSN:1078-5884
1532-2165
DOI:10.1016/j.ejvs.2005.05.002