Pattern‐reversal Visual Evoked Potentials in Patients with Newly Diagnosed Epilepsy

• Published in: Epilepsia (Copenhagen) 2005-08, Vol.46 (8), p.1219-1223
• Main Authors: Genç, Bülent O., Genç, Emine, Güney, Figen, İlhan, Nurhan
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Anticonvulsants. Antiepileptics. Antiparkinson agents; Biological and medical sciences; Cerebral Cortex - physiology; Cerebral Cortex - physiopathology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Diagnosis, Differential; Epilepsy - diagnosis; Epilepsy - physiopathology; Epilepsy, Reflex - diagnosis; Epilepsy, Reflex - physiopathology; Evoked Potentials, Visual - physiology; Female; Functional Laterality - physiology; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Male; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Neuropharmacology; Newly diagnosed epilepsy; Pattern Recognition, Visual - physiology; Pattern‐reversal visual evoked potentials (P‐VEPs); Pharmacology. Drug treatments; Reaction Time - physiology; Visual Pathways - physiology; Visual Pathways - physiopathology
• ISSN: 0013-9580; 1528-1167
• DOI: 10.1111/j.1528-1167.2005.63504.x

Purpose: The possible occurence of evoked potential (EP) abnormalities in patients with newly diagnosed epilepsy has been little investigated. The main purpose of the present study was to investigate possible changes in pattern‐reversal visual evoked potential (P‐VEP) responses in newly diagnosed epilepsy patients. Methods: By using P‐VEPs, latency values of the N75 and P100 together with amplitude values of P100 were recorded in newly diagnosed idiopathic epilepsy patients. The patients comprised two groups; nonphotosensitive (non‐PS), and photosensitive (PS) patients. Results: Shortened N75 and normal P100 latencies of the P‐VEP with higher than normal P100 amplitudes were detected in PS patients. In non‐PS patients, N75 latencies of the P‐VEPs were unaffected; however, P100 latencies were prolonged, and P100 amplitudes were unchanged. Conclusions: P‐VEPs are different from those of controls in previously untreated idiopathic epilepsy patients. Results also indicate different P‐VEP features in patients with and without photoparoxysmal responses. The changes might be the result of a disorder of one or more neurotransmitters or subtle morphologic damage such as microdysgenesis.