Bacterial genome sequencing and its use in infectious diseases

Summary The availability of genome sequences is revolutionising the fields of bacteriology and infectious diseases. By mid-2007, 479 bacterial genomes from 352 distinct species have been sequenced, including representatives of all notable human pathogens. Additionally, the genomes of several strains...

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Bibliographic Details
Published in:The Lancet infectious diseases 2007-11, Vol.7 (11), p.711-723
Main Authors: Fournier, Pierre-Edouard, MD, Drancourt, Michel, Prof, Raoult, Didier, Prof
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria - genetics
Bacteriology
Base Sequence
Biological and medical sciences
Communicable Disease Control
Communicable Diseases - microbiology
Fundamental and applied biological sciences. Psychology
Genetics
Genome, Bacterial
Humans
Infectious Disease
Infectious diseases
Microbiology
Molecular Sequence Data
Pathogens
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Summary:Summary The availability of genome sequences is revolutionising the fields of bacteriology and infectious diseases. By mid-2007, 479 bacterial genomes from 352 distinct species have been sequenced, including representatives of all notable human pathogens. Additionally, the genomes of several strains from each of 55 species have been sequenced. This tremendous amount of genomic data has led to unprecedented advances in pathogen diagnosis, genotyping, detection of virulence, and detection of resistance to antibiotics. We review current achievements in these fields and potential developments in the future for the clinical microbiology laboratory.
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(07)70260-8