Abdominal Adiposity Assessed by Dual Energy X-Ray Absorptiometry Provides a Sex-Independent Predictor of Insulin Sensitivity in Older Adults

Background. An increase in total adiposity and in particular an abdominal distribution of adiposity may contribute to the decline in metabolic insulin sensitivity observed in older men and women. The objective of this cross-sectional study was to determine which measure of abdominal adiposity would...

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Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2005-07, Vol.60 (7), p.872-877
Main Authors: Lee, Cathy C., Glickman, Scott G., Dengel, Donald R., Brown, Michael D., Supiano, Mark A.
Format: Article
Language:English
Subjects:
Abdomen
Absorptiometry, Photon
Adipose Tissue - metabolism
Aged
Aged, 80 and over
Aging - physiology
Blood Glucose - metabolism
Body Composition - physiology
Female
Follow-Up Studies
Gerontology
Glucose
Glucose Tolerance Test
Health risk assessment
Humans
Hypoglycemic Agents
Insulin
Insulin - blood
Insulin Resistance - physiology
Male
Medical disorders
Metabolism
Middle Aged
Older people
X-rays
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Summary:Background. An increase in total adiposity and in particular an abdominal distribution of adiposity may contribute to the decline in metabolic insulin sensitivity observed in older men and women. The objective of this cross-sectional study was to determine which measure of abdominal adiposity would provide the best sex-independent predictor of metabolic insulin sensitivity in older men and women. Methods. Insulin sensitivity and abdominal adiposity were measured in healthy, nondiabetic older (64 ± 6 years; mean ± standard deviation) men (n = 23) and women (n = 31). Metabolic Insulin Sensitivity Index (SI) was determined from a frequently sampled insulin-assisted intravenous glucose tolerance test. Body fat mass and abdominal fat mass were determined from dual energy X-ray absorptiometry (DXA) scans. Anthropometric measures included waist and hip circumferences, height, and body weight. Results. Although waist circumference, waist index (waist circumference divided by height), and waist–hip ratio (WHR) were all lower in women than in men, there was no sex difference in DXA L1–L4 fat mass. In univariate analyses, SI was significantly inversely related with body weight, body mass index, waist circumference, waist index, percentage of total body and abdominal fat, and DXA L1–L4 fat mass but not with WHR. The DXA L1–L4 fat mass was identified as the best independent predictor of SI, accounting for 41.2% of the variance (p
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/60.7.872