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Basic fibroblast growth factor reduces scar formation in acute incisional wounds
ABSTRACT In order to identify a means to reduce scar formation of the skin after incision, this study examined the effect of local administration of basic fibroblast growth factor (bFGF) in humans. bFGF was administered to a sutured wound immediately after an operation. The drug was injected once in...
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| Published in: | Wound repair and regeneration 2007-09, Vol.15 (5), p.617-623 |
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| Main Authors: | , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c5823-1412a55af34b0767c7343f37ac17082670ba1ab6d13d58fd26dceebcee9972c3 |
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| cites | cdi_FETCH-LOGICAL-c5823-1412a55af34b0767c7343f37ac17082670ba1ab6d13d58fd26dceebcee9972c3 |
| container_end_page | 623 |
| container_issue | 5 |
| container_start_page | 617 |
| container_title | Wound repair and regeneration |
| container_volume | 15 |
| creator | Ono, Ichiro Akasaka, Yoshikiyo Kikuchi, Risa Sakemoto, Akiko Kamiya, Takafumi Yamashita, Toshiharu Jimbow, Kowichi |
| description | ABSTRACT
In order to identify a means to reduce scar formation of the skin after incision, this study examined the effect of local administration of basic fibroblast growth factor (bFGF) in humans. bFGF was administered to a sutured wound immediately after an operation. The drug was injected once into the dermis of the margins of wounds using a 27G needle or rinsing after performing dermostitches. The lengths of the treated wounds varied from 1 to 32 cm, and the subjects were 2–86 years old. Sutured wounds after excision of skin tumors from the face, trunk, and limbs and sutured wounds such as those at the donor sites of full‐thickness skin grafts were treated with low‐dose bFGF injections (0.1 μg/cm wound; Group 2), high‐dose bFGF injections (1 μg/cm wound; Group 3), and rinsed with high‐dose bFGF (1 μg/cm wound; Group 4). No patient treated with bFGF had hypertrophic scars, while some patients had hypertrophic or very wide scars in the control group (Group 1), and the ratios of minimum scarring of Group 2 ( p |
| doi_str_mv | 10.1111/j.1524-475X.2007.00293.x |
| format | article |
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In order to identify a means to reduce scar formation of the skin after incision, this study examined the effect of local administration of basic fibroblast growth factor (bFGF) in humans. bFGF was administered to a sutured wound immediately after an operation. The drug was injected once into the dermis of the margins of wounds using a 27G needle or rinsing after performing dermostitches. The lengths of the treated wounds varied from 1 to 32 cm, and the subjects were 2–86 years old. Sutured wounds after excision of skin tumors from the face, trunk, and limbs and sutured wounds such as those at the donor sites of full‐thickness skin grafts were treated with low‐dose bFGF injections (0.1 μg/cm wound; Group 2), high‐dose bFGF injections (1 μg/cm wound; Group 3), and rinsed with high‐dose bFGF (1 μg/cm wound; Group 4). No patient treated with bFGF had hypertrophic scars, while some patients had hypertrophic or very wide scars in the control group (Group 1), and the ratios of minimum scarring of Group 2 ( p<0.001), Group 3 ( p<0.0001), and Group 4 ( p<0.0001) were statistically significantly higher than those of Group 1. Postoperative administration of bFGF inhibited hypertrophic scarring and widening of remaining scars without any serious side effects.</description><identifier>ISSN: 1067-1927</identifier><identifier>EISSN: 1524-475X</identifier><identifier>DOI: 10.1111/j.1524-475X.2007.00293.x</identifier><identifier>PMID: 17971006</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Basal Cell - surgery ; Child ; Child, Preschool ; Cicatrix - physiopathology ; Cicatrix - prevention & control ; Cicatrix, Hypertrophic - physiopathology ; Female ; Fibroblast Growth Factor 2 - administration & dosage ; Fibroblast Growth Factor 2 - physiology ; Humans ; Male ; Middle Aged ; Neoplasms, Squamous Cell - surgery ; Skin Neoplasms - surgery ; Suture Techniques ; Wound Healing - physiology</subject><ispartof>Wound repair and regeneration, 2007-09, Vol.15 (5), p.617-623</ispartof><rights>2007 by the Wound Healing Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5823-1412a55af34b0767c7343f37ac17082670ba1ab6d13d58fd26dceebcee9972c3</citedby><cites>FETCH-LOGICAL-c5823-1412a55af34b0767c7343f37ac17082670ba1ab6d13d58fd26dceebcee9972c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17971006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ono, Ichiro</creatorcontrib><creatorcontrib>Akasaka, Yoshikiyo</creatorcontrib><creatorcontrib>Kikuchi, Risa</creatorcontrib><creatorcontrib>Sakemoto, Akiko</creatorcontrib><creatorcontrib>Kamiya, Takafumi</creatorcontrib><creatorcontrib>Yamashita, Toshiharu</creatorcontrib><creatorcontrib>Jimbow, Kowichi</creatorcontrib><title>Basic fibroblast growth factor reduces scar formation in acute incisional wounds</title><title>Wound repair and regeneration</title><addtitle>Wound Repair Regen</addtitle><description>ABSTRACT
In order to identify a means to reduce scar formation of the skin after incision, this study examined the effect of local administration of basic fibroblast growth factor (bFGF) in humans. bFGF was administered to a sutured wound immediately after an operation. The drug was injected once into the dermis of the margins of wounds using a 27G needle or rinsing after performing dermostitches. The lengths of the treated wounds varied from 1 to 32 cm, and the subjects were 2–86 years old. Sutured wounds after excision of skin tumors from the face, trunk, and limbs and sutured wounds such as those at the donor sites of full‐thickness skin grafts were treated with low‐dose bFGF injections (0.1 μg/cm wound; Group 2), high‐dose bFGF injections (1 μg/cm wound; Group 3), and rinsed with high‐dose bFGF (1 μg/cm wound; Group 4). No patient treated with bFGF had hypertrophic scars, while some patients had hypertrophic or very wide scars in the control group (Group 1), and the ratios of minimum scarring of Group 2 ( p<0.001), Group 3 ( p<0.0001), and Group 4 ( p<0.0001) were statistically significantly higher than those of Group 1. Postoperative administration of bFGF inhibited hypertrophic scarring and widening of remaining scars without any serious side effects.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Basal Cell - surgery</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cicatrix - physiopathology</subject><subject>Cicatrix - prevention & control</subject><subject>Cicatrix, Hypertrophic - physiopathology</subject><subject>Female</subject><subject>Fibroblast Growth Factor 2 - administration & dosage</subject><subject>Fibroblast Growth Factor 2 - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms, Squamous Cell - surgery</subject><subject>Skin Neoplasms - surgery</subject><subject>Suture Techniques</subject><subject>Wound Healing - physiology</subject><issn>1067-1927</issn><issn>1524-475X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNkF1rHCEUhqW0NJ9_oXhVejOTo46eGchNG5oPEtKwBJI7cRyndTO7pjrDbv593O6S3pUK4os-7xEeQiiDkuV1Mi-Z5FVRoXwsOQCWALwR5fod2X97eJ8zKCxYw3GPHKQ0BwApm_oj2WPYIANQ--Tum0ne0t63MbSDSSP9GcNq_EV7Y8cQaXTdZF2iyZpI-xAXZvRhSf2SGjuNLgfrU74xA12FadmlI_KhN0Nyx7vzkNyff78_uyxuflxcnX29KaysuShYxbiR0vSiagEVWhSV6AUayxBqrhBaw0yrOiY6WfcdV511rs27aZBbcUg-b8c-x_B7cmnUC5-sGwazdGFKWtWVRMEhg1_-CTKsQWYvDDNab1EbQ0rR9fo5-oWJL5qB3njXc73Rqzd69ca7_uNdr3P10-6XqV247m9xJzoDp1tg5Qf38t-D9cNslkOuF9u6T6Nbv9VNfNIKBUr9cHuhuby8rWfXSivxCoqfoLg</recordid><startdate>200709</startdate><enddate>200709</enddate><creator>Ono, Ichiro</creator><creator>Akasaka, Yoshikiyo</creator><creator>Kikuchi, Risa</creator><creator>Sakemoto, Akiko</creator><creator>Kamiya, Takafumi</creator><creator>Yamashita, Toshiharu</creator><creator>Jimbow, Kowichi</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200709</creationdate><title>Basic fibroblast growth factor reduces scar formation in acute incisional wounds</title><author>Ono, Ichiro ; Akasaka, Yoshikiyo ; Kikuchi, Risa ; Sakemoto, Akiko ; Kamiya, Takafumi ; Yamashita, Toshiharu ; Jimbow, Kowichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5823-1412a55af34b0767c7343f37ac17082670ba1ab6d13d58fd26dceebcee9972c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Basal Cell - surgery</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cicatrix - physiopathology</topic><topic>Cicatrix - prevention & control</topic><topic>Cicatrix, Hypertrophic - physiopathology</topic><topic>Female</topic><topic>Fibroblast Growth Factor 2 - administration & dosage</topic><topic>Fibroblast Growth Factor 2 - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasms, Squamous Cell - surgery</topic><topic>Skin Neoplasms - surgery</topic><topic>Suture Techniques</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ono, Ichiro</creatorcontrib><creatorcontrib>Akasaka, Yoshikiyo</creatorcontrib><creatorcontrib>Kikuchi, Risa</creatorcontrib><creatorcontrib>Sakemoto, Akiko</creatorcontrib><creatorcontrib>Kamiya, Takafumi</creatorcontrib><creatorcontrib>Yamashita, Toshiharu</creatorcontrib><creatorcontrib>Jimbow, Kowichi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Wound repair and regeneration</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ono, Ichiro</au><au>Akasaka, Yoshikiyo</au><au>Kikuchi, Risa</au><au>Sakemoto, Akiko</au><au>Kamiya, Takafumi</au><au>Yamashita, Toshiharu</au><au>Jimbow, Kowichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Basic fibroblast growth factor reduces scar formation in acute incisional wounds</atitle><jtitle>Wound repair and regeneration</jtitle><addtitle>Wound Repair Regen</addtitle><date>2007-09</date><risdate>2007</risdate><volume>15</volume><issue>5</issue><spage>617</spage><epage>623</epage><pages>617-623</pages><issn>1067-1927</issn><eissn>1524-475X</eissn><abstract>ABSTRACT
In order to identify a means to reduce scar formation of the skin after incision, this study examined the effect of local administration of basic fibroblast growth factor (bFGF) in humans. bFGF was administered to a sutured wound immediately after an operation. The drug was injected once into the dermis of the margins of wounds using a 27G needle or rinsing after performing dermostitches. The lengths of the treated wounds varied from 1 to 32 cm, and the subjects were 2–86 years old. Sutured wounds after excision of skin tumors from the face, trunk, and limbs and sutured wounds such as those at the donor sites of full‐thickness skin grafts were treated with low‐dose bFGF injections (0.1 μg/cm wound; Group 2), high‐dose bFGF injections (1 μg/cm wound; Group 3), and rinsed with high‐dose bFGF (1 μg/cm wound; Group 4). No patient treated with bFGF had hypertrophic scars, while some patients had hypertrophic or very wide scars in the control group (Group 1), and the ratios of minimum scarring of Group 2 ( p<0.001), Group 3 ( p<0.0001), and Group 4 ( p<0.0001) were statistically significantly higher than those of Group 1. Postoperative administration of bFGF inhibited hypertrophic scarring and widening of remaining scars without any serious side effects.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17971006</pmid><doi>10.1111/j.1524-475X.2007.00293.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Wound repair and regeneration, 2007-09, Vol.15 (5), p.617-623 |
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| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Carcinoma, Basal Cell - surgery Child Child, Preschool Cicatrix - physiopathology Cicatrix - prevention & control Cicatrix, Hypertrophic - physiopathology Female Fibroblast Growth Factor 2 - administration & dosage Fibroblast Growth Factor 2 - physiology Humans Male Middle Aged Neoplasms, Squamous Cell - surgery Skin Neoplasms - surgery Suture Techniques Wound Healing - physiology |
| title | Basic fibroblast growth factor reduces scar formation in acute incisional wounds |
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