The fibrinogen gamma (FGG) 10034C>T polymorphism is associated with venous thrombosis

Abstract Introduction Thrombin-induced conversion of fibrinogen to fibrin plays an essential role in hemostasis and results in the stabilization of thrombi. Elevated plasma fibrinogen levels have been associated with both increased plasma viscosity and platelet aggregability. Recently, a haplotype-t...

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Bibliographic Details
Published in:Thrombosis research 2007, Vol.121 (1), p.33-36
Main Authors: Grünbacher, Gerda, Weger, Wolfgang, Marx-Neuhold, Ernestine, Pilger, Ernst, Köppel, Herwig, Wascher, Thomas, März, Winfried, Renner, Wilfried
Format: Article
Language:English
Subjects:
Adult
Aged
Atherosclerosis (general aspects, experimental research)
Austria - epidemiology
Biological and medical sciences
Blood and lymphatic vessels
Blood. Blood coagulation. Reticuloendothelial system
Cardiology. Vascular system
Case-Control Studies
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
DNA Mutational Analysis
Female
Fibrinogen
Fibrinogen - genetics
Genetic Predisposition to Disease
Genotype
Hematology, Oncology and Palliative Medicine
Humans
Male
Medical sciences
Middle Aged
Multivariate Analysis
Odds Ratio
Pharmacology. Drug treatments
Polymorphism
Polymorphism, Single Nucleotide
Risk factor
Risk Factors
Thrombosis
Venous Thrombosis - genetics
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Summary:Abstract Introduction Thrombin-induced conversion of fibrinogen to fibrin plays an essential role in hemostasis and results in the stabilization of thrombi. Elevated plasma fibrinogen levels have been associated with both increased plasma viscosity and platelet aggregability. Recently, a haplotype-tagging single nucleotide polymorphism characterized by a C to T substitution at nucleotide 10034 of the fibrinogen gamma gene (FGG 10034C>T, rs2066865), has been proposed as a novel risk factor for deep venous thrombosis (DVT). Aim of the present study was to provide further data on the role of the FGG 10034C>T polymorphism for DVT. Materials and methods FGG genotypes were determined by 5′-exonuclease assay (TaqMan) in 358 patients with documented DVT and a total of 783 control subjects. Results In a multivariate analysis adjusting for age, sex, presence of factor V Leiden and carriage of prothrombin 20210A, homozygosity for the FGG 10034 TT genotype yielded an odds ratio of 2.01 (95% CI 1.23–3.31; p = 0.006) for DVT. Conclusions Our data confirm the primary finding that the FGG 10034C>T polymorphism is associated with DVT risk.
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2007.03.007