Modulation of High-Density Lipoproteins in a Population in Istanbul, Turkey, With Low Levels of High-Density Lipoproteins

The extent to which high-density lipoprotein (HDL) cholesterol levels can be increased in patients with low HDL cholesterol is important because low HDL cholesterol levels increase the risk of coronary heart disease (CHD). During the past 14 years, we have assessed risk factors in Turks, a populatio...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2005-08, Vol.96 (4), p.547-555
Main Authors: Mahley, Robert W., Can, Selçuk, Özbayrakçı, Sinan, Bersot, Thomas P., Tanir, Sibel, Palaoğlu, K. Erhan, Pépin, Guy M.
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Biological and medical sciences
Body Mass Index
Cardiology
Cardiology. Vascular system
Cholesterol
Coronary Artery Disease - blood
Coronary Artery Disease - epidemiology
Coronary Artery Disease - etiology
Female
Follow-Up Studies
Humans
Life Style
Lipids
Lipoproteins, HDL - blood
Male
Medical sciences
Population Surveillance
Proteins
Retrospective Studies
Risk Factors
Sex Distribution
Socioeconomic Factors
Tangier Disease - blood
Tangier Disease - complications
Tangier Disease - epidemiology
Tangier Disease - prevention & control
Turkey - epidemiology
Urban Population
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The extent to which high-density lipoprotein (HDL) cholesterol levels can be increased in patients with low HDL cholesterol is important because low HDL cholesterol levels increase the risk of coronary heart disease (CHD). During the past 14 years, we have assessed risk factors in Turks, a population in which extremely low HDL cholesterol levels (mean 36 mg/dl in men, 42 mg/dl in women) are a prime CHD risk factor. Although genetically determined to a significant extent, these low HDL cholesterol levels can be modulated by lifestyle factors, as in other populations. We measured the HDL cholesterol levels in men and women residing in Istanbul at 3 time points: 1990 to 1993, 1996 to 2000, and 2003. The mean HDL cholesterol levels increased from 45.3 ± 9.5 mg/dl in 1990 to 1993 to 49.7 ± 12 mg/dl in 2003 (p 2 mg/dl at any of the 3 points. In conclusion, because CHD risk changes by as much as 2% to 4% per 1 mg/dl difference in HDL cholesterol level, the 8 mg/dl difference may reflect as much as a 20% to 30% reduction in CHD risk associated with the benefit of higher education in women. Why education failed to affect the HDL cholesterol levels in Turkish men remains unclear.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2005.04.018