Crossover interference underlies sex differences in recombination rates

In many organisms, recombination rates differ between the two sexes. Here we show that in mice, this is because of a shorter genomic interference distance in females than in males, measured in Mb. However, the interference distance is the same in terms of bivalent length. We propose a model in which...

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Bibliographic Details
Published in:Trends in genetics 2007-11, Vol.23 (11), p.539-542
Main Authors: Petkov, Petko M, Broman, Karl W, Szatkiewicz, Jin P, Paigen, Kenneth
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Crossing Over, Genetic
Female
Fundamental and applied biological sciences. Psychology
Genic rearrangement. Recombination. Transposable element
Male
Medical Education
Meiosis
Mice
Molecular and cellular biology
Molecular genetics
Pachytene Stage
Recombination, Genetic
Sex Characteristics
Sex Chromosomes
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Summary:In many organisms, recombination rates differ between the two sexes. Here we show that in mice, this is because of a shorter genomic interference distance in females than in males, measured in Mb. However, the interference distance is the same in terms of bivalent length. We propose a model in which the interference distance in the two sexes reflects the compaction of chromosomes at the pachytene stage of meiosis.
ISSN:0168-9525
DOI:10.1016/j.tig.2007.08.015