Systemic endothelial dysfunction in adults with cyanotic congenital heart disease

Secondary erythrocytosis results in increased shear stress in cyanotic congenital heart disease (CCHD), which may modify the balance between vasodilators and vasoconstrictors and affect systemic endothelial function. Because no data are available on systemic vasomotion, systemic endothelial function...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2005-08, Vol.112 (8), p.1106-1112
Main Authors: OECHSLIN, Erwin, KIOWSKI, Wolfgang, SCHINDLER, Ruth, BERNHEIM, Alain, JULIUS, Barbara, BRUNNER-LA ROCCA, Hans Peter
Format: Article
Language:English
Subjects:
Acetylcholine - administration & dosage
Adult
Antihypertensive Agents - administration & dosage
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cyanosis - physiopathology
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Endothelin-1 - administration & dosage
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiopathology
Enzyme Inhibitors - administration & dosage
Heart Defects, Congenital - physiopathology
Hemoglobins
Humans
Immunomodulators
Medical sciences
Microcirculation - drug effects
Microcirculation - physiology
Nitroprusside - administration & dosage
omega-N-Methylarginine - administration & dosage
Oxygen - blood
Peptides, Cyclic - administration & dosage
Pharmacology. Drug treatments
Polycythemia - physiopathology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Vasoconstriction - drug effects
Vasoconstriction - physiology
Vasodilation - drug effects
Vasodilation - physiology
Vasodilator Agents - administration & dosage
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Secondary erythrocytosis results in increased shear stress in cyanotic congenital heart disease (CCHD), which may modify the balance between vasodilators and vasoconstrictors and affect systemic endothelial function. Because no data are available on systemic vasomotion, systemic endothelial function and nitric oxide (NO) availability were investigated in CCHD patients. Responses to arterial endothelium-dependent (acetylcholine [Ach]) and -independent (sodium nitroprusside [SNP]) vasodilation, NO synthase blockade (NG-monomethyl-L-arginine [L-NMMA]), endothelin-1 (ET-1), and ET-1 receptor blockade by BQ-123 in 11 CCHD patients (O2 saturation
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.105.534073