T2N1M0 non-small cell lung cancer: surgery and prognostic factors

• Published in: Archivos de bronconeumología 2005-08, Vol.41 (8), p.430-433
• Main Authors: Padilla, J, Calvo, V, Peñalver, J C, Jordá, C, Escrivá, J, Cerón, J, García Zarza, A, Pastor, J, Blasco, E
• Format: Article
• Language: Spanish
• Subjects: Adult; Aged; Carcinoma, Bronchogenic - mortality; Carcinoma, Bronchogenic - pathology; Carcinoma, Bronchogenic - surgery; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - surgery; Female; Humans; Male; Middle Aged; Neoplasm Staging; Prognosis; Proportional Hazards Models; Survival Analysis
• ISSN: 0300-2896
• DOI: 10.1157/13077954

To determine the prognostic factors for the survival in a group of patients operated on for a non-small cell lung cancer classified as T2N1M0. Two hundred sixteen patients treated exclusively with surgery were studied. Kaplan-Meier survival and Cox multivariable regression analyses were used. The overall survival rate was 39.8% at 5 years and 29.9% at 10 years. Sex, age, presence or absence of symptoms, type of resection, number, and location of affected lymph nodes had no effect on survival. Tumor size (P=.04) and histologic type (P=.03) did significantly affect prognosis. Both variables entered into the Cox multivariable regression model. Patients operated on for non-small cell lung cancer classified as T2N1M0 have an overall probability of 5-year survival of approximately 40%. However, the prognosis for this group of patients is heterogeneous: in our study it was affected by the histologic type (45.5% for squamous cell and 25% for non-squamous cell cancers) and tumor size (53% for tumors with a diameter of 5 cm).