Colonization of neonate skin by Malassezia species: Relationship with neonatal cephalic pustulosis

• Published in: Journal of the American Academy of Dermatology 2007-12, Vol.57 (6), p.1012-1018
• Main Authors: Ayhan, Meltem, MD, Sancak, Banu, MD, Karaduman, Ayşen, MD, Arkan, Sevtap, MD, Şahin, Sedef, MD
• Format: Article
• Language: English
• Subjects: Acne Vulgaris - microbiology; Biological and medical sciences; Bullous diseases of the skin; Dermatology; Dermatomycoses - microbiology; Facial Dermatoses - microbiology; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases - microbiology; Malassezia - isolation & purification; Male; Medical sciences; Skin - microbiology
• ISSN: 0190-9622; 1097-6787
• DOI: 10.1016/j.jaad.2007.02.030

Background Colonization of neonate skin by Malassezia species and their causative role in neonatal cephalic pustulosis is unclear. Objectives We sought to determine the skin colonization by Malassezia in healthy newborns, and to investigate its association with neonatal cephalic pustulosis. Methods Samples for Malassezia colonization were taken from cheeks and scalps of 104 neonates between 24 and 72 hours after birth, and again 2 or 4 weeks later. Pustules were sampled with concomitant nonlesional skin cultures if neonatal cephalic pustulosis was diagnosed. Results Malassezia colonization increased significantly with age of the neonate (5% at the first week, 30% at 2-4 weeks). In all, 26 patients were given the diagnosis of neonatal cephalic pustulosis during follow-up. No correlation was found between the severity of the disease and Malassezia isolation. Skin colonization of patients with neonatal cephalic pustulosis (20.8%) was not higher than colonization of healthy newborns (37%). Limitations Not all of the neonates were examined by the authors at the second visit. Conclusions Malassezia colonization increases after the first week of life. No correlation was found between neonatal cephalic pustulosis and Malassezia.