Twice Weekly Fluconazole Prophylaxis for Prevention of Invasive Candida Infection in High-risk Infants of <1000 Grams Birth Weight

We tested the hypothesis that twice weekly prophylactic dosing of fluconazole prevents invasive candidiasis without promoting resistant Candida species in high-risk, preterm infants. We compared our previous dosing schedule (Group A) to a less frequent dosing schedule of twice a week (Group B) of fl...

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Bibliographic Details
Published in:The Journal of pediatrics 2005-08, Vol.147 (2), p.172-179
Main Authors: Kaufman, David, Boyle, Robert, Hazen, Kevin C., Patrie, James T., Robinson, Melinda, Grossman, Leigh B.
Format: Article
Language:English
Subjects:
Antifungal Agents - administration & dosage
Antifungal Agents - therapeutic use
Biological and medical sciences
Candida albicans - drug effects
Candida albicans - isolation & purification
Candidiasis - prevention & control
Catheterization, Central Venous
Double-Blind Method
Drug Administration Schedule
Female
Fluconazole - administration & dosage
Fluconazole - therapeutic use
General aspects
Gestational Age
Humans
Infant, Newborn
Infant, Very Low Birth Weight
Intensive Care Units, Neonatal
Intubation, Intratracheal
Male
Medical sciences
Microbial Sensitivity Tests
Risk Factors
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Summary:We tested the hypothesis that twice weekly prophylactic dosing of fluconazole prevents invasive candidiasis without promoting resistant Candida species in high-risk, preterm infants. We compared our previous dosing schedule (Group A) to a less frequent dosing schedule of twice a week (Group B) of fluconazole prophylaxis for up to 6 weeks in a prospective, randomized, double-blind clinical trial in preterm infants weighing
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2005.03.036