Chasing genes for mood disorders and schizophrenia in genetically isolated populations

Major affective disorders and schizophrenia are among the most common brain diseases worldwide and their predisposition is influenced by a complex interaction of genetic and environmental factors. So far, traditional linkage mapping studies for these complex disorders have not achieved the same succ...

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Bibliographic Details
Published in:Human mutation 2007-12, Vol.28 (12), p.1156-1170
Main Authors: Venken, Tine, Del-Favero, Jurgen
Format: Article
Language:English
Subjects:
association studies
Bipolar disorder
Bipolar Disorder - genetics
Brain diseases
Cloning
complex genetics
Emotional disorders
Genetic disorders
Genetic Linkage
Genetic Predisposition to Disease
Genetics
Genomics
Hallucinations
Humans
isolated population
linkage analysis
Mental depression
Mental disorders
Mood disorders
Mood Disorders - genetics
Mutation
Pathophysiology
Psychosis
Schizophrenia
Schizophrenia - genetics
Twins
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Summary:Major affective disorders and schizophrenia are among the most common brain diseases worldwide and their predisposition is influenced by a complex interaction of genetic and environmental factors. So far, traditional linkage mapping studies for these complex disorders have not achieved the same success as the positional cloning of genes for Mendelian diseases. The struggle to identify susceptibility genes for complex disorders has stimulated the development of alternative approaches, including studies in genetically isolated populations. Since isolated populations are likely to have both a reduced number of genetic vulnerability factors and environmental background and are therefore considered to be more homogeneous compared to outbred populations, the use of isolated populations in genetic studies is expected to improve the chance of finding susceptibility loci and genes. Here we review the role of isolated populations, based on linkage and association studies, in the identification of susceptibility genes for bipolar disorder and schizophrenia. Hum Mutat 28(12), 1156-1170, 2007. © 2007 Wiley-Liss, Inc.
ISSN:1059-7794
1098-1004
DOI:10.1002/humu.20582