Vitamin C supplementation affects oxidative-stress blood markers in response to a 30 minute run at 75% VO2max

Vitamin C supplementation (VC) (either 500 or 1000 mg/d for 2 wk) was compared to a placebo treatment (P) to ascertain if VC could influence oxidative stress. Twelve healthy males (25 +/- 1.4 y) were randomly assigned in a counter-balanced design with a 2-wk period between treatments. Data were anal...

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Bibliographic Details
Published in:International journal of sport nutrition and exercise metabolism 2005-06, Vol.15 (3), p.279-290
Main Authors: Goldfarb, A.H, Patrick, S.W, Bryer, S, You, T
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis of Variance
antioxidants
Antioxidants - administration & dosage
Antioxidants - pharmacology
ascorbic acid
Ascorbic Acid - administration & dosage
Ascorbic Acid - pharmacology
biomarkers
blood chemistry
Cross-Over Studies
Dietary Supplements
dose response
Dose-Response Relationship, Drug
exercise
exercise test
glutathione
Glutathione - blood
Glutathione - drug effects
Humans
lipid peroxidation
Lipid Peroxidation - drug effects
Lipid Peroxidation - physiology
Male
men
nutritional status
Oxidation-Reduction
oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - physiology
Oxygen Consumption
protective effect
proteolysis
running
Running - physiology
sports nutrition
Thiobarbituric Acid Reactive Substances - metabolism
thiobarbituric acid-reactive substances
vitamin supplements
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Summary:Vitamin C supplementation (VC) (either 500 or 1000 mg/d for 2 wk) was compared to a placebo treatment (P) to ascertain if VC could influence oxidative stress. Twelve healthy males (25 +/- 1.4 y) were randomly assigned in a counter-balanced design with a 2-wk period between treatments. Data were analyzed using repeated measures ANOVA. Exercise intensity measures (VO2, RER, RPE, HR, lactate) were similar across treatments. Resting blood oxidative-stress markers were unaffected by treatment. Exercise decreased total blood glutathione (TGSH) and reduced glutathione (GSH) and increased oxidized glutathione (GSSG) (P < 0.01) independent of treatment. Protein carbonyls (PC) increased 3.8 fold in the P (P < 0.01). VC attenuated the PC exercise response in a dose-dependent manner (P < 0.01). Thiobarbituric acid reactive substances (TBARS) was not influenced by exercise (P = 0.68) or VC. These data suggest that VC supplementation can attenuate exercise-induced protein oxidation in a dose-dependent manner with no effect on lipid peroxidation and glutathione status.
ISSN:1526-484X
1543-2742
DOI:10.1123/ijsnem.15.3.279