Cell transplantation therapy in re-animating severely head-injured patients

The results of controlled, retrospective clinical investigation of applying cell transplantation (CT) therapy in 38 severely head-injured patients are presented. The patients initially were in state of coma (Glasgow coma scale score 3--7), owing to their traumatic brain injuries. Cells prepared from...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2005-08, Vol.59 (7), p.415-420
Main Authors: Seledtsov, Victor I, Rabinovich, Samuil S, Parlyuk, Oleg V, Kafanova, Marina Yu, Astrakov, Sergey V, Seledtsova, Galina V, Samarin, Denis M, Poveschenko, Olga V
Format: Article
Language:English
Subjects:
Adolescent
Adult
Brain Injuries - therapy
Brain Tissue Transplantation
Cell Transplantation
Craniocerebral Trauma - therapy
Female
Fetal Tissue Transplantation
Humans
Liver - cytology
Magnetic Resonance Imaging
Male
Middle Aged
Retrospective Studies
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Summary:The results of controlled, retrospective clinical investigation of applying cell transplantation (CT) therapy in 38 severely head-injured patients are presented. The patients initially were in state of coma (Glasgow coma scale score 3--7), owing to their traumatic brain injuries. Cells prepared from fetal nervous and hematopoietic tissues were grafted subarachnoidally via lumbar puncture. The control group consisted of 38 patients and was clinically comparable with the trial one. From the results obtained it appears that CT treatment promoted both wakening consciousness of the patients and their following neurological rehabilitation. A death-rate in the trial and control group was 5% (two cases) and 45% (17 cases), respectively. According to a Glasgow scale, favorable (good+satisfactory) outcomes of a disease were noted in 33 (87%) cell-grafted and only in 15 (39%) control patients. Statistical analysis revealed that CT treatment generally improved the outcomes by 2.5-fold. No serious complications of CT therapy were noted. The results point out a possible rationality of applying CT therapy in severely head-injured patients as early as within acute period of a disease.
ISSN:0753-3322