Investigations and management of gastrointestinal and hepatic manifestations of systemic lupus erythematosus

Gastrointestinal (GI) manifestations of systemic lupus erythematosus (SLE) are protean. Any part of the GI tract and the hepatobiliary system can be involved. Up to two-third of SLE patients develop GI symptoms at some stage of their illnesses. Clinical presentations of GI lupus are non-specific and...

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Bibliographic Details
Published in:Best practice & research. Clinical rheumatology 2005-10, Vol.19 (5), p.741-766
Main Author: Mok, C.C.
Format: Article
Language:English
Subjects:
abdomen
complications
Diagnostic Imaging - methods
Endoscopy, Gastrointestinal - methods
Gastrointestinal Diseases - diagnosis
Gastrointestinal Diseases - etiology
Gastrointestinal Diseases - therapy
gut
hepatitis
Humans
Immunosuppressive Agents - therapeutic use
liver
Liver Diseases - diagnosis
Liver Diseases - etiology
Liver Diseases - therapy
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - therapy
morbidity
serositis
Treatment Outcome
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Summary:Gastrointestinal (GI) manifestations of systemic lupus erythematosus (SLE) are protean. Any part of the GI tract and the hepatobiliary system can be involved. Up to two-third of SLE patients develop GI symptoms at some stage of their illnesses. Clinical presentations of GI lupus are non-specific and can be difficult to differentiate from infective, thrombotic, therapy-related and non-SLE etiologies. Clinical acumen and appropriate endoscopic, biopsy and imaging procedures are essential for establishing the correct diagnosis. Acute abdominal pain in SLE patients can herald an intra-abdominal catastrophe and should be evaluated promptly. Surgical intervention should be instituted without delay if conservative management fails or when there is clinical or radiological suspicion of visceral perforation or intra-abdominal collections.
ISSN:1521-6942
1532-1770
DOI:10.1016/j.berh.2005.04.002