The Management and Outcome of Patients with Germ-cell Tumours Treated in the Edinburgh Cancer Centre Between 1988 and 2002

The aim of this retrospective analysis was to review the outcome of patients with germ-cell tumours treated in the Edinburgh Cancer Centre over the past 15 years, and to see whether there had been any changes over three 5-year cohorts. Patients referred with gonadal and extra-gonadal primary germ-ce...

Full description

Saved in:
Bibliographic Details
Published in:Clinical oncology (Royal College of Radiologists (Great Britain)) 2005-09, Vol.17 (6), p.435-440
Main Authors: Howard, G.C.W., Conkey, D.S., Peoples, S., McLaren, D.B., Hargreave, T.B., Tulloch, D.N., Walker, W., Kerr, G.R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Combined Modality Therapy
Disease-Free Survival
Germ-cell tumours
Humans
Male
Middle Aged
Neoplasm Staging
Neoplasms, Germ Cell and Embryonal - mortality
Neoplasms, Germ Cell and Embryonal - pathology
Neoplasms, Germ Cell and Embryonal - therapy
prognostic group
Retrospective Studies
Risk Factors
Survival Rate
testicular cancer
Testicular Neoplasms - mortality
Testicular Neoplasms - pathology
Testicular Neoplasms - therapy
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this retrospective analysis was to review the outcome of patients with germ-cell tumours treated in the Edinburgh Cancer Centre over the past 15 years, and to see whether there had been any changes over three 5-year cohorts. Patients referred with gonadal and extra-gonadal primary germ-cell tumours, between 1988 and 2002, were identified from the departmental database, and survival by stage and prognostic group was analysed. The proportion of patients with stage I seminoma has significantly increased. The good prognosis of patients with early stage disease is confirmed, with the outcome for some groups of patients being better than expected. There is a non-significant trend to improved results over the three 5-year cohorts. The outcome for patients with stage IV seminoma is worse than would be expected, but numbers are small. The poor prognosis of patients with non-seminomatous germ-cell tumours who fall into the International Germ Cell Consensus Classification (IGCCC) poor-prognostic group is confirmed. Failure of patients with metastatic non-seminomatous germ-cell tumours to achieve a complete response to initial therapy is shown to be a poor prognostic indicator.
ISSN:0936-6555
1433-2981
DOI:10.1016/j.clon.2005.03.011