Association of the A870G cyclin D1 gene polymorphism with genetic susceptibility to nasopharyngeal carcinoma

Background. Nasopharyngeal cancer (NPC) is multifactorial, and the genetic background may be a crucial etiologic factor. Cyclin D1 (CCND1) is a key regulator of the cell cycle, and its altered activity is associated with the development of cancer. Methods. We analyzed the A870G CCND1 polymorphism by...

Full description

Saved in:
Bibliographic Details
Published in:Head & neck 2006-07, Vol.28 (7), p.603-608
Main Authors: Catarino, Raquel J., Breda, Eduardo, Coelho, Vânia, Pinto, Daniela, Sousa, Hugo, Lopes, Carlos, Medeiros, Rui
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
cancer risk
cyclin D1
Female
Genes, bcl-1 - genetics
genetic polymorphism
Genetic Predisposition to Disease - genetics
Genotype
head and neck
Humans
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
nasopharyngeal cancer
Nasopharyngeal Neoplasms - genetics
Nasopharyngeal Neoplasms - pathology
Odds Ratio
Otorhinolaryngology. Stomatology
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. Nasopharyngeal cancer (NPC) is multifactorial, and the genetic background may be a crucial etiologic factor. Cyclin D1 (CCND1) is a key regulator of the cell cycle, and its altered activity is associated with the development of cancer. Methods. We analyzed the A870G CCND1 polymorphism by polymerase chain reaction/restriction fragment length polymorphism (PCR‐RFLP) in 281 individuals, including 94 patients with NPC and 187 healthy individuals. Results. Our results indicate that individuals carrying two G alleles have a 2.17‐fold increase in the risk for the development of NPC (odds ratio [OR], 2.17; 95% confidence interval [CI], 1.19–3.98; p = .016). Age‐adjusted logistic regression analysis confirmed this association (adjusted odds ratio [aOR], 2.14; 95% CI, 1.14–4.04; p = .018). Multivariate analysis demonstrates an independent association between GG CCND1 genotype (aOR, 2.06), male sex (aOR, 2.66), and age at diagnosis (aOR, 2.02) regarding the development of undifferentiated NPC. The proportion of NPC cases attributable to the GG CCND1 genotype was 14.76%. Conclusions. Our results may be important in the definition of a biologic predictive profile for the development of NPC within our population. © 2006 Wiley Periodicals, Inc. Head Neck, 2006
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.20377