Timing and mechanism of ancient vertebrate genome duplications – the adventure of a hypothesis

Complete genome doubling has long-term consequences for the genome structure and the subsequent evolution of an organism. It has been suggested that two genome duplications occurred at the origin of vertebrates (known as the 2R hypothesis). However, there has been considerable debate as to whether t...

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Bibliographic Details
Published in:Trends in genetics 2005-10, Vol.21 (10), p.559-567
Main Authors: Panopoulou, Georgia, Poustka, Albert J.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Genes, Homeobox - genetics
Genetics of eukaryotes. Biological and molecular evolution
Genome
Models, Genetic
Molecular and cellular biology
Phylogeny
Polyploidy
Vertebrates - genetics
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Summary:Complete genome doubling has long-term consequences for the genome structure and the subsequent evolution of an organism. It has been suggested that two genome duplications occurred at the origin of vertebrates (known as the 2R hypothesis). However, there has been considerable debate as to whether these were two successive duplications, or whether a single duplication occurred, followed by large-scale segmental duplications. In this article, we review and compare the evidence for the 2R duplications from vertebrate genomes with similar data from other more recent polyploids.
ISSN:0168-9525
DOI:10.1016/j.tig.2005.08.004