Validation of portal vein flow measurement by color flow Doppler sonography in a porcine model of septic shock

• Published in: Intensive care medicine 2005-09, Vol.31 (9), p.1288-1291
• Main Authors: ZÜLKE, Carl, MATEJOVIC, Martin, TRÄGER, Karl, RADERMACHER, Peter
• Format: Article
• Language: English
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Biological and medical sciences; Blood and lymphatic vessels; Blood flow; Blood Flow Velocity; Cardiology. Vascular system; Cardiovascular system; Care and treatment; Case studies; Diagnosis; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Doppler effect; Doppler ultrasonography; Intensive care; Intensive care medicine; Investigations; Investigative techniques, diagnostic techniques (general aspects); Laboratories; Medical sciences; Portal Vein - diagnostic imaging; Positive-Pressure Respiration; Septic shock; Shock, Septic - diagnostic imaging; Shock, Septic - physiopathology; Swine; Ultrasonic imaging; Ultrasonic investigative techniques; Ultrasonography, Doppler, Color; Veins & arteries; Ventilators
• ISSN: 0342-4642; 1432-1238
• DOI: 10.1007/s00134-005-2722-1

To compare portal vein flow values gained by color flow Doppler sonography with simultaneously derived data from an ultrasound transit time flow probe. Repeated, simultaneous flow measurements were performed in a prospective study investigating the effect of various drugs on hepatosplanchnic perfusion and energy balance in a long-term model of stable, hyperdynamic endotoxin shock. Investigational animal laboratory. Domestic pigs. Alterations in respirator setting were studied with regard to their effect on the quality of color flow Doppler data in comparison to flow probe data. Additional experiments included variation in PEEP level in conjunction with volume resuscitation. Respiratory rates of 14-18/min led to color Doppler flow values consistently 20-40% above simultaneously measured flow probe data. Temporary apnea led to enhanced agreement of data. Reduction in respiratory rate to 8/min with increase in tidal volume consistently led to color Doppler data within 10% of the corresponding flow probe values. A short-term period of respirator-dependent, constant portal vein inflow enables color Doppler sonography to detect correct values in a clinically relevant setting of hyperdynamic endotoxin shock.