Frontal Dysfunction Underlies Depressive Syndrome in Alzheimer Disease: A FDG-PET Study

This study aimed to investigate the regional cerebral dysfunction associated with depressive syndrome in patients with Alzheimer disease (AD). Twelve patients with AD with depressive syndrome (ADD) and 12 age-, gender-, and severity-matched patients with AD without depressive syndrome (ADND) underwe...

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Bibliographic Details
Published in:The American journal of geriatric psychiatry 2006-07, Vol.14 (7), p.625-628
Main Authors: Lee, Dong Young, Choo, Il Han, Jhoo, Jin Hyeong, Kim, Ki Woong, Youn, Jong Choul, Lee, Dong Su, Kang, Eun Joo, Lee, Jae Sung, Kang, Won Jun, Woo, Jong In
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - physiopathology
Alzheimer's disease
Depressive Disorder, Major - diagnostic imaging
Depressive Disorder, Major - physiopathology
depressive syndrome
FDG-PET
Female
Fluorodeoxyglucose F18 - pharmacokinetics
frontal dysfunction
Frontal Lobe - metabolism
Frontal Lobe - physiopathology
Humans
Male
Positron-Emission Tomography
Radiopharmaceuticals - pharmacokinetics
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Summary:This study aimed to investigate the regional cerebral dysfunction associated with depressive syndrome in patients with Alzheimer disease (AD). Twelve patients with AD with depressive syndrome (ADD) and 12 age-, gender-, and severity-matched patients with AD without depressive syndrome (ADND) underwent FDG-PET scanning. The regional cerebral glucose metabolism in the two groups was compared using a voxel-based method. The ADD group showed lower glucose metabolism in the right superior frontal gyrus than the ADND group. These results indicate that frontal dysfunction, known to be associated with primary or other secondary depressive syndromes, underlies the depressive syndrome of patients with AD patients as well.
ISSN:1064-7481
1545-7214
DOI:10.1097/01.JGP.0000214541.79965.2d