Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis

The plant homodomain (PHD) of ING2 was shown to regulate p53-dependent apoptosis through phosphoinositides signaling. However, the role of a predicted leucine zipper-like (LZL) motif in N-terminus of ING2 is unclear. Here, we show that LZL motif is critical for the proper functions of ING2 in DNA re...

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Bibliographic Details
Published in:FEBS letters 2006-07, Vol.580 (16), p.3787-3793
Main Authors: Wang, Yemin, Wang, Jing, Li, Gang
Format: Article
Language:English
Subjects:
Acetylation
Apoptosis
Apoptosis - radiation effects
Chromatin Assembly and Disassembly
DNA Repair
DNA, Neoplasm - genetics
DNA, Neoplasm - metabolism
DNA, Neoplasm - radiation effects
E1A-Associated p300 Protein - metabolism
HAT
HDAC
Histone acetylation
histone acetyltransferase
histone deacetylase
Histones - metabolism
Homeodomain Proteins - chemistry
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
Humans
ING2
leucine zipper-like
Leucine zipper-like domain
Leucine Zippers
LZL
NER
nucleotide excision repair
p53
PCNA
PCNA-interacting protein
PCR
PHD
PIP
plant homeodomain
potential chromatin regulatory
proliferating cell nuclear antigen
Protein Binding
Protein Structure, Tertiary
Receptors, Cytoplasmic and Nuclear - chemistry
Receptors, Cytoplasmic and Nuclear - genetics
Receptors, Cytoplasmic and Nuclear - metabolism
Tumor Cells, Cultured
Tumor Suppressor Protein p53 - metabolism
Tumor Suppressor Proteins - chemistry
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
Ultraviolet Rays
wild-type
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Summary:The plant homodomain (PHD) of ING2 was shown to regulate p53-dependent apoptosis through phosphoinositides signaling. However, the role of a predicted leucine zipper-like (LZL) motif in N-terminus of ING2 is unclear. Here, we show that LZL motif is critical for the proper functions of ING2 in DNA repair, apoptosis and chromatin remodeling after UV irradiation. Deletion of LZL domain also abrogated the association between ING2 and p53, but not between ING2 and p300, suggesting that ING2 modulates p53-dependent chromatin remodeling, apoptosis and DNA repair by functioning as a scaffold protein to mediate the interaction between p53 and p300.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2006.05.065