Low Pre-radiotherapy Prostate-specific Antigen Level is a Significant Predictor of Treatment Success for Postoperative Radiotherapy in Patients with Prostate Cancer

Background: The optimal role of postoperative radiotherapy for patients with prostate cancer remains undefined. Materials and Methods: The medical records of 70 patients (median age: 66 years), who had received radical radiotherapy (RT) between the years 1996 and 2004 after radical prostatectomy (RP...

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Bibliographic Details
Published in:Anticancer research 2006-05, Vol.26 (3B), p.2367-2374
Main Authors: SASAKI, Tomonari, NAKAMURA, Katsumasa, NOMA, Hideya, KOMATSU, Kiyoshi, YAMAGUCHI, Akito, HIRATSUKA, Yoshiharu, HIRANO, Tomomi, HANADA, Kiyohiko, ABE, Madoka, FUJISAWA, Yasuhito, HONDA, Hiroshi, SHIOYAMA, Yoshiyuki, OHGA, Saiji, TOBA, Takashi, URASHIMA, Yusuke, YOSHITAKE, Tadamasa, TERASHIMA, Hiromi, KOGA, Hirofumi, NAITO, Seiji
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Disease-Free Survival
Humans
Male
Medical sciences
Middle Aged
Neoplasm Staging
Nephrology. Urinary tract diseases
Predictive Value of Tests
Prostate-Specific Antigen - blood
Prostatectomy
Prostatic Neoplasms - blood
Prostatic Neoplasms - pathology
Prostatic Neoplasms - radiotherapy
Prostatic Neoplasms - surgery
Radiotherapy, Adjuvant
Retrospective Studies
Salvage Therapy
Tumors
Tumors of the urinary system
Urinary tract. Prostate gland
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Summary:Background: The optimal role of postoperative radiotherapy for patients with prostate cancer remains undefined. Materials and Methods: The medical records of 70 patients (median age: 66 years), who had received radical radiotherapy (RT) between the years 1996 and 2004 after radical prostatectomy (RP), were analyzed. Fifteen patients had received immediate adjuvant RT, while the other 55 patients had received salvage therapy. Hormonal therapy had been performed in 28 patients before RT and continued in two of them concurrently with RT. A median dose of 60 Gy was delivered to the prostate bed. Pelvic node irradiation was performed in all patients. Results: After a median follow-up period of 23 months, 21 patients had experienced biochemical failure. Actuarial 3- and 5-year biochemical relapse-free survival estimates were 67.4%. No patient had local failure, although distant metastases with biochemical failure were found in five patients. On univariate analysis, the following were significant for biochemical failures: seminar vesicle involvement, serum PSA level >1 ng/ml before RT, pathological pelvic node involvement, RT indication (adjuvant vs. salvage) and Gleason score. However, only the serum PSA level before RT was significant on multivariate analysis. Conclusion: Postoperative RT with a pre-RT PSA level
ISSN:0250-7005
1791-7530