Mu opioid receptors are extensively co-localized with parvalbumin, but not somatostatin, in the dentate gyrus

In the rat dentate gyrus, mu opioid receptor (MOR) agonists disinhibit principal cells, promoting excitation, but whether MOR protein is differentially distributed to interneuron subtypes is unknown. Here, the distribution of MOR immunoreactivity was semi-quantitatively examined in neurochemically i...

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Bibliographic Details
Published in:Neuroscience letters 2006-07, Vol.403 (1), p.176-180
Main Authors: Drake, Carrie T., Milner, Teresa A.
Format: Article
Language:English
Subjects:
Animals
Dentate Gyrus - metabolism
Hippocampus
Immunohistochemistry
Interneurons - metabolism
Male
Microscopy, Fluorescence
Opiate
Parvalbumin
Parvalbumins - metabolism
Rats
Rats, Sprague-Dawley
Receptors, Opioid, mu - metabolism
Somatostatin
Somatostatin - metabolism
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Summary:In the rat dentate gyrus, mu opioid receptor (MOR) agonists disinhibit principal cells, promoting excitation, but whether MOR protein is differentially distributed to interneuron subtypes is unknown. Here, the distribution of MOR immunoreactivity was semi-quantitatively examined in neurochemically identified interneurons using fluorescence microscopy. We find that MOR- and parvalbumin-immunoreactivities are frequently co-localized, while MOR- and somatostatin-immunoreactivities are less commonly co-localized. This suggests that MORs are most frequently on interneurons specialized to inhibit granule cell output, and are on a limited number of interneurons that inhibit granule cell distal dendrites.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2006.04.047