Exercise training protects the renal circulation against high glucose challenge

It has been shown previously that high glucose causes direct and acute endothelial dysfunction in non‐diabetic isolated rabbit kidney. This study assessed whether exercise training is able to maintain normal renal vascular endothelial function despite high glucose exposure. Animals were pen confined...

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Bibliographic Details
Published in:Fundamental & clinical pharmacology 2005-10, Vol.19 (5), p.537-543
Main Authors: De Moraes, Roger, Gioseffi, Giovanni, Lopes, Nuno do Nascimento, Gomes, Marilia Brito, Nóbrega, Antonio Claudio Lucas, Tibiriçá, Eduardo
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Animals
Biological and medical sciences
diabetes mellitus
Diabetes. Impaired glucose tolerance
Dose-Response Relationship, Drug
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Endothelium, Vascular - physiology
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Exercise Test - methods
Female
Glucose - administration & dosage
Glucose - pharmacology
hyperglycemia
In Vitro Techniques
Injections, Intravenous
isolated rabbit kidney
Kidney - blood supply
Kidney - drug effects
Kidney - physiology
Male
Medical sciences
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - physiology
Pharmacology. Drug treatments
Physical Conditioning, Animal - methods
Physical Conditioning, Animal - physiology
Rabbits
Renal Circulation - drug effects
Renal Circulation - physiology
Time Factors
vascular reactivity
Vasodilation - drug effects
Vasodilator Agents - pharmacology
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Summary:It has been shown previously that high glucose causes direct and acute endothelial dysfunction in non‐diabetic isolated rabbit kidney. This study assessed whether exercise training is able to maintain normal renal vascular endothelial function despite high glucose exposure. Animals were pen confined (SED) or treadmill trained over a 12‐week period (ExT). Kidneys isolated from SED and ExT rabbits were continuously perfused ex vivo during 3 h with Krebs–Henseleit solutions containing normal (5.5 mm) or high (15 mm) concentrations of d‐glucose. In the SED 5.5 group, acetylcholine (ACh) induced dose‐related vasodilator responses, reaching the maximum of 41 ± 2% (n = 10; P 
ISSN:0767-3981
1472-8206
DOI:10.1111/j.1472-8206.2005.00358.x