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Intraindividual Variability and the Effect of Acute Illness on Immune Senescence Markers
Objectives: To determine the intraindividual variability and effect of acute illness on two markers of immune senescence. Design: Cohort study with repeated measures. Setting: Clinical research center and emergency department at two academic medical centers. Participants: Seventy‐three subjects aged...
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| Published in: | Journal of the American Geriatrics Society (JAGS) 2005-10, Vol.53 (10), p.1761-1766 |
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| container_end_page | 1766 |
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| container_title | Journal of the American Geriatrics Society (JAGS) |
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| creator | High, Kevin P. Trader, Melissa Pahor, Marco Loeb, Mark |
| description | Objectives: To determine the intraindividual variability and effect of acute illness on two markers of immune senescence.
Design: Cohort study with repeated measures.
Setting: Clinical research center and emergency department at two academic medical centers.
Participants: Seventy‐three subjects aged 65 and older enrolled in three groups: chronic underlying conditions but no acute illness, acutely ill with infection (community‐acquired pneumonia), and acutely ill without infection.
Measurements: CD16 density on polymorphonuclear neutrophils (PMNs) and the proportion of CD8+ T cells that express CD28 determined twice in the nonacutely ill group and three times (Days 0, 30, and 60) in the acute illness groups.
Results: In the nonacutely ill group, PMN CD16 density demonstrated wide intraindividual variation, but there was a strong correlation for repeated measures of the percentage of CD8+ T cells expressing CD28 (correlation coefficient (r)=0.77, P |
| doi_str_mv | 10.1111/j.1532-5415.2005.53526.x |
| format | article |
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Design: Cohort study with repeated measures.
Setting: Clinical research center and emergency department at two academic medical centers.
Participants: Seventy‐three subjects aged 65 and older enrolled in three groups: chronic underlying conditions but no acute illness, acutely ill with infection (community‐acquired pneumonia), and acutely ill without infection.
Measurements: CD16 density on polymorphonuclear neutrophils (PMNs) and the proportion of CD8+ T cells that express CD28 determined twice in the nonacutely ill group and three times (Days 0, 30, and 60) in the acute illness groups.
Results: In the nonacutely ill group, PMN CD16 density demonstrated wide intraindividual variation, but there was a strong correlation for repeated measures of the percentage of CD8+ T cells expressing CD28 (correlation coefficient (r)=0.77, P<.001). Acute illness markedly affected both measures, regardless of whether the illness was due to infection; there was no correlation between measures obtained on Day 0 versus Day 30 for either immune marker. In contrast, a strong correlation existed between Day 30 and Day 60 values, particularly for CD8+/CD28+ percentage (r=0.58–0.86; P=.006 to <.001).
Conclusion: The percentage of CD8+ T cells that express CD28 is a highly reproducible marker of immune senescence. Although acute illness affects this marker, 30 to 60 days of convalescence appears adequate for it to return to baseline.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/j.1532-5415.2005.53526.x</identifier><identifier>PMID: 16181177</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Inc</publisher><subject>Acute Disease ; Age Factors ; Aged ; Biological and medical sciences ; CD16 ; CD28 ; CD28 Antigens - blood ; CD8 ; CD8-Positive T-Lymphocytes - immunology ; Chronic Disease ; Chronic illnesses ; Clinical outcomes ; Community-Acquired Infections - immunology ; Female ; General aspects ; Geriatric Assessment ; Geriatrics ; Humans ; immune senescence ; Immune system ; Immunologic Factors - blood ; Individuality ; intraindividual variability ; Lymphocyte Count ; Male ; Medical sciences ; Neutrophils - immunology ; Pneumonia, Bacterial - immunology ; Receptors, IgG - blood ; Reproducibility of Results ; Statistics as Topic</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2005-10, Vol.53 (10), p.1761-1766</ispartof><rights>2005 INIST-CNRS</rights><rights>2005 by the American Geriatrics Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4636-7d2eb4af9783c629c8adcfc74df5c4291fa9f832e88433b5aaa5a0eab6ef11be3</citedby><cites>FETCH-LOGICAL-c4636-7d2eb4af9783c629c8adcfc74df5c4291fa9f832e88433b5aaa5a0eab6ef11be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17213587$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16181177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>High, Kevin P.</creatorcontrib><creatorcontrib>Trader, Melissa</creatorcontrib><creatorcontrib>Pahor, Marco</creatorcontrib><creatorcontrib>Loeb, Mark</creatorcontrib><title>Intraindividual Variability and the Effect of Acute Illness on Immune Senescence Markers</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>Objectives: To determine the intraindividual variability and effect of acute illness on two markers of immune senescence.
Design: Cohort study with repeated measures.
Setting: Clinical research center and emergency department at two academic medical centers.
Participants: Seventy‐three subjects aged 65 and older enrolled in three groups: chronic underlying conditions but no acute illness, acutely ill with infection (community‐acquired pneumonia), and acutely ill without infection.
Measurements: CD16 density on polymorphonuclear neutrophils (PMNs) and the proportion of CD8+ T cells that express CD28 determined twice in the nonacutely ill group and three times (Days 0, 30, and 60) in the acute illness groups.
Results: In the nonacutely ill group, PMN CD16 density demonstrated wide intraindividual variation, but there was a strong correlation for repeated measures of the percentage of CD8+ T cells expressing CD28 (correlation coefficient (r)=0.77, P<.001). Acute illness markedly affected both measures, regardless of whether the illness was due to infection; there was no correlation between measures obtained on Day 0 versus Day 30 for either immune marker. In contrast, a strong correlation existed between Day 30 and Day 60 values, particularly for CD8+/CD28+ percentage (r=0.58–0.86; P=.006 to <.001).
Conclusion: The percentage of CD8+ T cells that express CD28 is a highly reproducible marker of immune senescence. Although acute illness affects this marker, 30 to 60 days of convalescence appears adequate for it to return to baseline.</description><subject>Acute Disease</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>CD16</subject><subject>CD28</subject><subject>CD28 Antigens - blood</subject><subject>CD8</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Chronic Disease</subject><subject>Chronic illnesses</subject><subject>Clinical outcomes</subject><subject>Community-Acquired Infections - immunology</subject><subject>Female</subject><subject>General aspects</subject><subject>Geriatric Assessment</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>immune senescence</subject><subject>Immune system</subject><subject>Immunologic Factors - blood</subject><subject>Individuality</subject><subject>intraindividual variability</subject><subject>Lymphocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neutrophils - immunology</subject><subject>Pneumonia, Bacterial - immunology</subject><subject>Receptors, IgG - blood</subject><subject>Reproducibility of Results</subject><subject>Statistics as Topic</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkUtv1DAURi0EokPhLyALCXYJfsSxs0GqqjIzUB5Sh8LOcpxr4SGP1k5g5t_jdEatxApvbF2f--n6GCFMSU7TervNqeAsEwUVOSNE5IILVua7R2hxf_EYLQghLFMlLU7Qsxi3hFBGlHqKTmhJFaVSLtCPdT8G4_vG__bNZFp8bYI3tW_9uMemb_D4E_CFc2BHPDh8ZqcR8Lpte4gRDz1ed93UA76CVLDQW8CfTPgFIT5HT5xpI7w47qfo2_uLzfkqu_yyXJ-fXWa2KHmZyYZBXRhXScVtySqrTGOdlUXjhC1YRZ2pnOIMlCo4r4UxRhgCpi7BUVoDP0VvDrk3YbidII6682mStjU9DFPUZXp_KSRJ4Kt_wO0whT7NphklXEpSFQlSB8iGIcYATt8E35mw15ToWb3e6tmwng3rWb2-U693qfXlMX-qO2geGo-uE_D6CJhoTeuC6a2PD5xklAs1c-8O3B_fwv6_B9Aflld3xxSQHQJ8HGF3H5D-RZeSS6G_f17qavN1s7pefdRL_hf-tq6-</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>High, Kevin P.</creator><creator>Trader, Melissa</creator><creator>Pahor, Marco</creator><creator>Loeb, Mark</creator><general>Blackwell Science Inc</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200510</creationdate><title>Intraindividual Variability and the Effect of Acute Illness on Immune Senescence Markers</title><author>High, Kevin P. ; Trader, Melissa ; Pahor, Marco ; Loeb, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4636-7d2eb4af9783c629c8adcfc74df5c4291fa9f832e88433b5aaa5a0eab6ef11be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acute Disease</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>CD16</topic><topic>CD28</topic><topic>CD28 Antigens - blood</topic><topic>CD8</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Chronic Disease</topic><topic>Chronic illnesses</topic><topic>Clinical outcomes</topic><topic>Community-Acquired Infections - immunology</topic><topic>Female</topic><topic>General aspects</topic><topic>Geriatric Assessment</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>immune senescence</topic><topic>Immune system</topic><topic>Immunologic Factors - blood</topic><topic>Individuality</topic><topic>intraindividual variability</topic><topic>Lymphocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neutrophils - immunology</topic><topic>Pneumonia, Bacterial - immunology</topic><topic>Receptors, IgG - blood</topic><topic>Reproducibility of Results</topic><topic>Statistics as Topic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>High, Kevin P.</creatorcontrib><creatorcontrib>Trader, Melissa</creatorcontrib><creatorcontrib>Pahor, Marco</creatorcontrib><creatorcontrib>Loeb, Mark</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>High, Kevin P.</au><au>Trader, Melissa</au><au>Pahor, Marco</au><au>Loeb, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraindividual Variability and the Effect of Acute Illness on Immune Senescence Markers</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2005-10</date><risdate>2005</risdate><volume>53</volume><issue>10</issue><spage>1761</spage><epage>1766</epage><pages>1761-1766</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract>Objectives: To determine the intraindividual variability and effect of acute illness on two markers of immune senescence.
Design: Cohort study with repeated measures.
Setting: Clinical research center and emergency department at two academic medical centers.
Participants: Seventy‐three subjects aged 65 and older enrolled in three groups: chronic underlying conditions but no acute illness, acutely ill with infection (community‐acquired pneumonia), and acutely ill without infection.
Measurements: CD16 density on polymorphonuclear neutrophils (PMNs) and the proportion of CD8+ T cells that express CD28 determined twice in the nonacutely ill group and three times (Days 0, 30, and 60) in the acute illness groups.
Results: In the nonacutely ill group, PMN CD16 density demonstrated wide intraindividual variation, but there was a strong correlation for repeated measures of the percentage of CD8+ T cells expressing CD28 (correlation coefficient (r)=0.77, P<.001). Acute illness markedly affected both measures, regardless of whether the illness was due to infection; there was no correlation between measures obtained on Day 0 versus Day 30 for either immune marker. In contrast, a strong correlation existed between Day 30 and Day 60 values, particularly for CD8+/CD28+ percentage (r=0.58–0.86; P=.006 to <.001).
Conclusion: The percentage of CD8+ T cells that express CD28 is a highly reproducible marker of immune senescence. Although acute illness affects this marker, 30 to 60 days of convalescence appears adequate for it to return to baseline.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Inc</pub><pmid>16181177</pmid><doi>10.1111/j.1532-5415.2005.53526.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Acute Disease Age Factors Aged Biological and medical sciences CD16 CD28 CD28 Antigens - blood CD8 CD8-Positive T-Lymphocytes - immunology Chronic Disease Chronic illnesses Clinical outcomes Community-Acquired Infections - immunology Female General aspects Geriatric Assessment Geriatrics Humans immune senescence Immune system Immunologic Factors - blood Individuality intraindividual variability Lymphocyte Count Male Medical sciences Neutrophils - immunology Pneumonia, Bacterial - immunology Receptors, IgG - blood Reproducibility of Results Statistics as Topic |
| title | Intraindividual Variability and the Effect of Acute Illness on Immune Senescence Markers |
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