Loading…
Influence of Positive End-Expiratory Pressure Ventilation on Survival During Severe Hemorrhagic Shock
Although a moderate positive end-expiratory pressure (PEEP) level is widely recommended, it is unknown whether moderate PEEP during mechanical ventilation has adverse effects during severe hemorrhagic shock. Therefore, the purpose of our study was to evaluate the effects of 0 cm H 2O PEEP versus 5 c...
Saved in:
Published in: | Annals of emergency medicine 2005-10, Vol.46 (4), p.337-342 |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Although a moderate positive end-expiratory pressure (PEEP) level is widely recommended, it is unknown whether moderate PEEP during mechanical ventilation has adverse effects during severe hemorrhagic shock. Therefore, the purpose of our study was to evaluate the effects of 0 cm H
2O PEEP versus 5 cm H
2O PEEP versus 10 cm H
2O PEEP on short-term survival in a porcine model of severe hemorrhagic shock. Secondary study endpoints were hemodynamic variables and blood gases.
Twenty-four anesthetized pigs were bled approximately 45 mL/kg, randomized into 3 groups, and then ventilated with 0, 5, or 10 cm H
2O PEEP. Survival rates were compared using Kaplan-Meier methods with log rank (Mantel Cox) comparison of cumulative survival by treatment group.
Seven of 8 0 cm H
2O PEEP animals survived the 120-minute study period, but 8 of 8 5 cm H
2O PEEP animals died within 30 minutes, and 8 of 8 10 cm H
2O PEEP animals were dead within 20 minutes (
P |
---|---|
ISSN: | 0196-0644 1097-6760 |
DOI: | 10.1016/j.annemergmed.2005.02.022 |