Role of compensatory mammary growth in epigenetic control of gene expression

To better understand the role of nutrition in regulating mammary gland development and lactation, we designed a novel stair-step compensatory nutrition regimen that is a unique combination of dietary energy restriction and realimentation (refeeding) phases; the basic concept of this regimen is to ex...

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Bibliographic Details
Published in:The FASEB journal 2005-10, Vol.19 (12), p.1586-1591
Main Author: Park, Chung S
Format: Article
Language:English
Subjects:
Animal Feed
Animal Nutritional Physiological Phenomena
Animals
Cattle
Cell Differentiation
Cell Proliferation
compensatory growth
Epigenesis, Genetic
epigenetics
Food Deprivation
Gene Expression
Gene Expression Regulation
Gene Expression Regulation, Developmental
Genomic Imprinting
Growth Substances
Immunoglobulins - metabolism
lactation potential
mammary development
Mammary Glands, Animal - embryology
Mammary Glands, Animal - pathology
metabolic imprinting
Models, Biological
Rats
RNA, Messenger - metabolism
Species Specificity
Swine
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Summary:To better understand the role of nutrition in regulating mammary gland development and lactation, we designed a novel stair-step compensatory nutrition regimen that is a unique combination of dietary energy restriction and realimentation (refeeding) phases; the basic concept of this regimen is to exploit the biological nature of the compensatory growth phenomenon in concert with one or more hormone-sensitive allometric phases of mammary development (i.e., peripuberty through gestation). Nutritionally induced compensatory growth during different developmental stages before first parturition positively affects mammary development and life-long lactation performance. This permanent enhancement of mammary gland growth and lactation potential strongly suggests a possible mechanistic link between nutritionally induced compensatory growth, epigenetic control of mammary gene expression, and metabolic imprinting. We hypothesize that compensatory-directed metabolic imprinting once set during late pregnancy prior to the first parturition persistently maintains and exerts its adaptive response on mammogenesis and galactopoiesis (i.e., maintenance and/or enhancement of milk secretion). The ability to influence heritable genes regulating milk synthesis may be used to improve the quality and quantity of milk (e.g., infant health, the secretion of certain immunoglobulins or growth factors) as well as the longevity of lactation.--Park, C. S. Role of compensatory mammary growth in epigenetic control of gene expression.
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.05-3816hyp