Persistent B19 infection in immunocompetent individuals: implications for transfusion safety

Recent reports suggested that parvovirus B19 (B19) might persist in immunocompetent individuals such as blood donors, but only cross-sectional data were available. Serial samples from a cohort of multitransfused patients with hemoglobinopathies and a cross-sectional population of pregnant women were...

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Bibliographic Details
Published in:Blood 2005-10, Vol.106 (8), p.2890-2895
Main Authors: Lefrère, Jean-Jacques, Servant-Delmas, Annabelle, Candotti, Daniel, Mariotti, Martine, Thomas, Isabelle, Brossard, Yvon, Lefrère, François, Girot, Robert, Allain, Jean-Pierre, Laperche, Syria
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Child
Child, Preschool
Cross-Sectional Studies
DNA, Viral - analysis
DNA, Viral - genetics
Female
Genomics
Humans
Immunocompetence - immunology
Infant
Longitudinal Studies
Male
Medical sciences
Middle Aged
Parvoviridae Infections - immunology
Parvoviridae Infections - transmission
Parvoviridae Infections - virology
Parvovirus B19, Human - genetics
Parvovirus B19, Human - isolation & purification
Parvovirus B19, Human - physiology
Polymerase Chain Reaction
Safety
Sensitivity and Specificity
Transfusion Reaction
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Summary:Recent reports suggested that parvovirus B19 (B19) might persist in immunocompetent individuals such as blood donors, but only cross-sectional data were available. Serial samples from a cohort of multitransfused patients with hemoglobinopathies and a cross-sectional population of pregnant women were tested for B19 markers. Of 76 red cell recipients, 6 (8%) had persistent viral DNA for 1 to 3 or more years, depending on the sensitivity of the genomic amplification assay. All patients also carried B19-specific immunoglobulin G (IgG). In contrast, 0.8% of 500 pregnant women carried both detectable B19 DNA and specific IgG. These results demonstrate that persistence of low levels of B19 DNA suggested by cross-sectional studies is frequent in multitransfused patients and that the virus may remain detectable several years after infection in nonimmunodeficient individuals. (Blood. 2005;106:2890-2895)
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2005-03-1053