Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection

T cell responses are important to the control of infection but are deleterious if not regulated. IFN-gamma-deficient mice infected with mycobacteria exhibit enhanced accumulation of activated effector T cells and neutrophils within granulomatous lesions. These cells do not control bacterial growth a...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2006-08, Vol.177 (3), p.1416-1420
Main Authors: Cruz, Andrea, Khader, Shabaana A, Torrado, Egidio, Fraga, Alexandra, Pearl, John E, Pedrosa, Jorge, Cooper, Andrea M, Castro, António G
Format: Article
Language:English
Subjects:
Animals
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
CD4-Positive T-Lymphocytes - microbiology
Cell Differentiation - immunology
Cell Proliferation
Cells, Cultured
Dendritic Cells - immunology
Dendritic Cells - metabolism
Dendritic Cells - microbiology
Growth Inhibitors - physiology
Interferon-gamma - physiology
Interleukin-12 - biosynthesis
Interleukin-17 - antagonists & inhibitors
Interleukin-17 - biosynthesis
Interleukin-23
Interleukin-23 Subunit p19
Interleukins - biosynthesis
Interleukins - deficiency
Interleukins - genetics
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Mycobacterium bovis - immunology
Tuberculosis - immunology
Tuberculosis - pathology
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Summary:T cell responses are important to the control of infection but are deleterious if not regulated. IFN-gamma-deficient mice infected with mycobacteria exhibit enhanced accumulation of activated effector T cells and neutrophils within granulomatous lesions. These cells do not control bacterial growth and compromise the integrity of the infected tissue. We show that IFN-gamma-deficient mice have increased numbers of IL-17-producing T cells following infection with Mycobacterium bovis bacille Calmette Guérin. Furthermore, exogenous IFN-gamma increases IL-12 and decreases IL-23 production by bacille Calmette Guérin-infected bone marrow-derived dendritic cells and reduces the frequency of IL-17-producing T cells induced by these bone marrow-derived dendritic cells. These data support the hypothesis that, during mycobacterial infection, both IFN-gamma- and IL-17-producing T cells are induced, but that IFN-gamma serves to limit the IL-17-producing T cell population. This counterregulation pathway may be an important factor in limiting mycobacterially associated immune-mediated pathology.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.177.3.1416