Clinicopathological Features of and Risk Factors for Multiple Primary Melanomas

CONTEXT The incidence of multiple primary melanomas ranges from 1.3% to 8.0% in large retrospective reviews; however, the impact of certain risk factors is not understood. OBJECTIVES To determine the incidence of multiple primary melanomas (MPM) from a prospective, single-institution, multidisciplin...

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Published in:JAMA : the journal of the American Medical Association 2005-10, Vol.294 (13), p.1647-1654
Main Authors: Ferrone, Cristina R, Ben Porat, Leah, Panageas, Katherine S, Berwick, Marianne, Halpern, Allan C, Patel, Ami, Coit, Daniel G
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Child
Child, Preschool
Cohort Studies
Dermatology
Disease
Female
General aspects
Humans
Incidence
Infant
Male
Medical sciences
Melanoma - epidemiology
Melanoma - pathology
Middle Aged
Neoplasms, Multiple Primary - epidemiology
Neoplasms, Multiple Primary - pathology
Neoplasms, Second Primary - epidemiology
Neoplasms, Second Primary - pathology
Pathology
Risk Factors
Skin Neoplasms - epidemiology
Skin Neoplasms - pathology
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:CONTEXT The incidence of multiple primary melanomas ranges from 1.3% to 8.0% in large retrospective reviews; however, the impact of certain risk factors is not understood. OBJECTIVES To determine the incidence of multiple primary melanomas (MPM) from a prospective, single-institution, multidisciplinary database, and to describe the clinical and pathological characteristics and risk factors specific to these patients. DESIGN AND SETTING Review of a prospectively maintained database at Memorial Sloan-Kettering Cancer Center in New York, NY. PATIENTS A total of 4484 patients diagnosed with a first primary melanoma between January 1, 1996, and December 31, 2002. MAIN OUTCOME MEASURES Incidence of and risk factors for MPM. RESULTS Three hundred eighty-five patients (8.6%) had 2 or more primary melanomas, with an average of 2.3 melanomas per MPM patient. Seventy-eight percent had 2 primary melanomas. For 74% of patients, the initial melanoma was the thickest tumor. Fifty-nine percent presented with their second primary tumor within 1 year. Twenty-one percent of MPM patients had a positive family history of melanoma compared with only 12% of patients with a single primary melanoma (SPM) (P
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.294.13.1647