Indications on suitable scaffold as carrier of stem cells in the alveoloplasty of cleft palate

summary  Autologous iliac crest bone is used to close the residual alveolar bone defect in cleft palate patients during late mixed dentition. Surgery involves physical and anaesthesiologic risks, long‐time hospitalization, high costs and not always good results (15% failure rate). Alternatives to il...

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Bibliographic Details
Published in:Journal of oral rehabilitation 2006-08, Vol.33 (8), p.625-629
Main Authors: PAGANELLI, C, FONTANA, P., PORTA, F, MAJORANA, A, PAZZAGLIA, U. E., SAPELLI, P. L.
Format: Article
Language:English
Subjects:
Alveoloplasty - methods
Animals
Bone Transplantation - methods
cleft palate
Cleft Palate - surgery
Dentistry
Fibrin Foam
Humans
iliac crest bone grafting
Ilium - transplantation
Rats
scaffold
Spongostan
Stem Cell Transplantation - methods
stem cells
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Summary:summary  Autologous iliac crest bone is used to close the residual alveolar bone defect in cleft palate patients during late mixed dentition. Surgery involves physical and anaesthesiologic risks, long‐time hospitalization, high costs and not always good results (15% failure rate). Alternatives to iliac crest bone grafting are going to be evaluated: synthetic, xenograft and allograft matrices combined with platelet‐rich plasma or recombined bone morphogenic proteins for osteoinductivity are commercially available. These alternatives have not yet been determined to be equivalent to the previous treatment. A new field of research is represented by stem cells, which have been also used to regenerate ischaemic cardiac tissue after heart attack, to treat hypophosphatasia and osteoporosis. Our aim was to use osteoblasts from stem cells to close the residual palate cleft in association with a suitable carrier. Stem cells are expanded in the Aastrom bioreactor, differentiated into osteoblasts and positioned in the bone defect by means of a Spongostan® scaffold. This scaffold has the best characteristics as commercial availability, low cost, good manageability, absence of allergic reactions or other side effects on patient, biocompatibility, imbibition, radiotransparency, reabsorbability and osteoinductivity. Previous studies encourage Spongostan scaffold application.
ISSN:0305-182X
1365-2842
DOI:10.1111/j.1365-2842.2005.01594.x