The importance of housing conditions on behavioral sensitization and tolerance to ethanol

The differential outcomes of social isolation and crowding environment on the effects of single or repeated administration of ethanol on open-field behavior were examined in female mice. Whereas housing conditions did not alter the increase in locomotor activity induced by ethanol single administrat...

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Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2005-09, Vol.82 (1), p.40-45
Main Authors: Araujo, Nilza Pereira, Camarini, Rosana, Souza-Formigoni, Maria Lucia O., Carvalho, Rita C., Abílio, Vanessa C., Silva, Regina H., Ricardo, Victor Proença, Ribeiro, Rosana de Alencar, Frussa-Filho, Roberto
Format: Article
Language:English
Subjects:
Animal ethology
Animals
Behavior, Animal - drug effects
Behavioral sensitization
Biological and medical sciences
Crowding
Drug Tolerance
Ethanol
Ethanol - pharmacology
Female
Fundamental and applied biological sciences. Psychology
Housing
Mammalia
Mice
Psychology. Psychoanalysis. Psychiatry
Social Isolation
Vertebrata
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Summary:The differential outcomes of social isolation and crowding environment on the effects of single or repeated administration of ethanol on open-field behavior were examined in female mice. Whereas housing conditions did not alter the increase in locomotor activity induced by ethanol single administration, behavioral sensitization (a progressive increase of a drug effect following repeated drug administration) to the locomotor activating effect of ethanol was significantly greater in crowded mice as compared to isolated and control groups. Single administration of ethanol significantly decreased rearing frequency and increased immobility duration, there being tolerance to these ethanol behavior effects after repeated treatment. Social isolation attenuated the increase in immobility behavior induced by single administration of ethanol and potentiated the tolerance of ethanol-induced rearing decrease, verified after repeated treatment. These results point out that both sensitization and tolerance to the behavioral effects of ethanol can be critically influenced by housing conditions.
ISSN:0091-3057
1873-5177
DOI:10.1016/j.pbb.2005.07.009