Adolescent siblings with thigh pain at the same age

• Published in: The Lancet (British edition) 2005-10, Vol.366 (9493), p.1330-1330
• Main Authors: Shirado, Osamu, Nomoto, Tomohisa, Kuwazawa, Yasuyuki, Kim, Yoon Taek, Oda, Hiromi, Hirose, Takanori
• Format: Article
• Language: English
• Subjects: Adolescent; Bone Neoplasms - complications; Bone Neoplasms - genetics; Bones; Chromosome aberrations; Female; Femoral Neoplasms - diagnosis; Femoral Neoplasms - surgery; Histology; Humans; Legs; Lesions; Lymphocytes; Muscle pain; Nonsteroidal anti-inflammatory drugs; Osteoblastoma - diagnosis; Osteoblastoma - surgery; Osteoma, Osteoid - diagnosis; Osteoma, Osteoid - surgery; Pain; Pain - etiology; Siblings; Spinal Neoplasms - diagnosis; Spinal Neoplasms - surgery; Teenagers; Thigh; Tumors
• ISSN: 0140-6736; 1474-547X
• DOI: 10.1016/S0140-6736(05)67533-2

In May, 2004, our patient's 13-year-old sister was brought to our clinic because of a 1-year history of pain in her left thigh. The mother was worried that her younger daughter might also have a bone tumour. On examination, she had limited motion and tenderness of her left hip joint; routine blood tests were normal. A plain radiograph of her left femur showed an intracortical, rounded, radiolucent lesion, surrounded by sclerotic bone, with periosteal bone reaction. CT showed a lytic lesion medially in the left proximal femur. En bloc resection of the tumour and autologous bone grafting were done; histology showed osteoid osteoma (figure, B). There were no chromosome aberrations in peripheral lymphocytes of the two sisters or their family members. Fluorescence in situ hybridisation analysis of the resected tumour tissue showed no chromosome alterations involving 22q.1 When last seen in June, 2005, the sisters were pain free, and there was no recurrence of bone tumours radiographically.