Myocardial infarction is associated with Spl binding site polymorphism of collagen type 1A1 gene

Human atherosclerotic lesions contain collagen type I, which plays a pivotal role in atherosclerotic plaque stability. In contrast, the normal coronary arteries do not express this type of collagen. Data have shown that the collagen type 1A1 (COL1A1) gene Sp1 binding site (-1245 G/T) polymorphism is...

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Bibliographic Details
Published in:Acta cardiologica 2006-06, Vol.61 (3), p.321-325
Main Authors: Speer, Gábor, Szenthe, Péter, Kósa, János P, Tabák, Adám G, Folhoffer, Anikó, Fuszek, Péter, Cseh, Károly, Lakatos, Péter
Format: Article
Language:English
Subjects:
Adiponectin - blood
Adult
Aged
Alleles
Biomarkers, Tumor - genetics
Blood Glucose - metabolism
Body Mass Index
C-Reactive Protein - metabolism
Collagen Type I - genetics
Coronary Artery Disease - blood
Coronary Artery Disease - diagnosis
Coronary Artery Disease - genetics
Female
Follow-Up Studies
Genetic Carrier Screening
Genetic Predisposition to Disease - genetics
Genotype
Homozygote
Humans
Insulin Resistance - genetics
Male
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Myocardial Infarction - genetics
Polymerase Chain Reaction
Polymorphism, Genetic - genetics
Polymorphism, Restriction Fragment Length
Receptors, Immunologic - genetics
Reference Values
Risk Factors
Transcription, Genetic
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Summary:Human atherosclerotic lesions contain collagen type I, which plays a pivotal role in atherosclerotic plaque stability. In contrast, the normal coronary arteries do not express this type of collagen. Data have shown that the collagen type 1A1 (COL1A1) gene Sp1 binding site (-1245 G/T) polymorphism is associated with disturbed collagen protein production. In our study, COL1A1 gene Sp1 polymorphism was investigated in 136 patients with myocardial infarction (MI) 5 months after the acute phase, and 212 age-matched control subjects in association with any cardiovascular risk factors (such as serum adiponectin levels, hyperinsulinaemic status, hyperlipaemia). The "SS" genotype of the COL1A1 gene was found to occur significantly more frequently in patients surviving a MI, as compared to the control group and the "Ss" and "ss" genotype frequencies (the presence of the s allele) were lower in our patients, than in control group. However, the occurrence of cardiovascular risk factors was significantly higher among the "s" allelic carriers as compared to patients carrying the "S" allele of the COL1A1 gene. Our results raise the possibility that COL1A1 gene Sp1 polymorphism might have an impact on the development of MI.
ISSN:0001-5385