Signaling molecularly imprinted polymers: molecular recognition-based sensing materials

Molecular imprinting is a template polymerization technique that can easily provide synthetic polymers capable of molecular recognition for given target molecules. In addition to their highly specific recognition ability, we are attempting to introduce signaling functions to molecularly imprinted po...

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Bibliographic Details
Published in:Chemical record 2005, Vol.5 (5), p.263-275
Main Authors: Takeuchi, Toshifumi, Mukawa, Takashi, Shinmori, Hideyuki
Format: Article
Language:English
Subjects:
Acrylates - chemistry
Biosensing Techniques
Cinchona Alkaloids - chemistry
Cinchona Alkaloids - metabolism
fluorescent monomers
Hydrogen Bonding
metalloporphyrins
Metalloporphyrins - chemistry
molecular imprinting
molecular recognition
Molecular Structure
Polymers - chemistry
Polymers - metabolism
signaling molecularly imprinted polymers
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Summary:Molecular imprinting is a template polymerization technique that can easily provide synthetic polymers capable of molecular recognition for given target molecules. In addition to their highly specific recognition ability, we are attempting to introduce signaling functions to molecularly imprinted polymers, enabling them to respond according to specific binding events. Some of our work regarding such signaling molecularly imprinted polymers is presented here, including molecularly imprinted polymers that induce spectral shifts of target compounds because of binding. Such compounds include hydrogen‐bonding‐based fluorescent imprinted polymers and metalloporphyrin‐based signaling molecularly imprinted polymers. © 2005 The Japan Chemical Journal Forum and Wiley Periodicals, Inc. Chem Rec 5: 263–275; 2005: Published online in Wiley InterScience (www.interscience.wiley.com) DOI 10.1002/tcr.20052 Signaling molecularly imprinted polymers can specifically bind target molecules and signal the binding events by the change of spectroscopic properties of the targets and/or the polymers. Here, we describe two ways to signal the binding: one is that the imprinted polymers cause an emission wavelength shift in the fluorescent target molecules by binding like shift reagents, and the other is that a fluorescence enhancement or spectral change in the imprinted polymers bearing a fluorophore or a chromophore results from the binding events.
ISSN:1527-8999
1528-0691
DOI:10.1002/tcr.20052