Contrast Sensitivity and Color Vision in HIV-infected Individuals Without Infectious Retinopathy

• Published in: American journal of ophthalmology 2006-08, Vol.142 (2), p.284-292.e2
• Main Authors: Shah, Kayur H., Holland, Gary N., Yu, Fei, Van Natta, Mark, Nusinowitz, Steven
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; Adult; AIDS; Antiretroviral drugs; Antiretroviral Therapy, Highly Active; Biological and medical sciences; Color blindness; Color Perception - physiology; Contrast Sensitivity - physiology; Cross-Sectional Studies; HIV; HIV Infections - drug therapy; HIV Infections - physiopathology; Human immunodeficiency virus; Human viral diseases; Humans; Infectious diseases; Medical sciences; Middle Aged; Miscellaneous; Ophthalmology; Prevalence; Retinopathies; Risk Factors; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Vision Disorders - diagnosis; Vision Disorders - physiopathology; Vision Tests
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/j.ajo.2006.03.046

To investigate the relationship between abnormal contrast sensitivity and abnormal color vision among human immunodeficiency virus (HIV)-infected individuals who have normal visual acuity and to seek host factors that predict these abnormalities. Noninterventional, cross-sectional study. We evaluated 71 HIV-infected subjects with visual acuity of 20/25 or better, clear media, and no vision-threatening retinal lesions. Visual function was determined using the Pelli-Robson contrast sensitivity test and the Farnsworth-Munsell 100-Hue color test (FM-100). Results were compared with published values for normal populations and to measures of HIV disease severity. We evaluated two levels of impairment for each visual function. “Mild dysfunction” was defined as ≥1 standard deviation (SD), but