Augmentation of fatality of influenza in mice by inhibition of phagocytosis

Influenza virus-infected cells undergo apoptosis and become susceptible to phagocytosis by macrophages, and this leads to the inhibition of virus propagation in vitro. To assess if this were also true in vivo, mice infected with influenza A/WSN (H1N1) virus were administered with phagocytosis inhibi...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2005-11, Vol.337 (3), p.881-886
Main Authors: Watanabe, Yuichi, Hashimoto, Yumi, Shiratsuchi, Akiko, Takizawa, Takenori, Nakanishi, Yoshinobu
Format: Article
Language:English
Subjects:
Animals
Annexin A5 - pharmacology
Apoptosis
Female
Inflammation
Influenza A virus - pathogenicity
Influenza virus
Mice
Mice, Inbred BALB C
Oligosaccharides - pharmacology
Orthomyxoviridae Infections - physiopathology
Orthomyxoviridae Infections - virology
Phagocytosis
Phagocytosis - drug effects
Pneumonia - physiopathology
Pneumonia - virology
Severity of Illness Index
Survival Analysis
Survival Rate
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Summary:Influenza virus-infected cells undergo apoptosis and become susceptible to phagocytosis by macrophages, and this leads to the inhibition of virus propagation in vitro. To assess if this were also true in vivo, mice infected with influenza A/WSN (H1N1) virus were administered with phagocytosis inhibitors and examined for the progress of influenza. Administration of the inhibitors caused a decrease in the level of phagocytosis observed with bronchoalveolar lavage cells. We found that both the lethality in mice and the extent of inflammation in the lung were augmented in those mice. These results suggest that phagocytosis of virus-infected cells helps suppress the progress of influenza in mice.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2005.09.133