ARYL NUCLEOSIDE H-PHOSPHONATES AS A TOOL FOR INVESTIGATION OF STEREOSPECIFICITY DURING COUPLING

It was found that in stereoselective condensations of ribonucleoside 3′-H-phosphonates with alcohols, the major diastereomer of the produced H-phosphonate diesters is formed from the minor diastereomer of the intermediate phosphonic-pivalic anhydride.

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2005-01, Vol.24 (5-7), p.887-890
Main Authors: Sobkowski, Michal, Jankowska, Jadwiga, Stawinski, Jacek, Kraszewski, Adam
Format: Article
Language:English
Subjects:
H-phosphonates
Magnetic Resonance Spectroscopy
Models, Chemical
Molecular Biology - methods
Molecular Conformation
Nucleosides - chemistry
Nucleotides - chemistry
Organophosphonates - chemistry
P NMR Spectroscopy
Stereoisomerism
Stereospecific Coupling
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Description
Summary:It was found that in stereoselective condensations of ribonucleoside 3′-H-phosphonates with alcohols, the major diastereomer of the produced H-phosphonate diesters is formed from the minor diastereomer of the intermediate phosphonic-pivalic anhydride.
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-200059239