Diastereoselective Cobalt-Catalyzed Reductive Aldol Cyclizations Using Diethylzinc as the Stoichiometric Reductant

Cobalt catalysis enables a new method for the generation of zinc enolates using diethylzinc to reduce α,β-unsaturated amides. This method has been applied to a high-yielding diastereoselective reductive aldol cyclization.

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Bibliographic Details
Published in:Organic letters 2006-08, Vol.8 (17), p.3729-3732
Main Authors: Lam, Hon Wai, Joensuu, Pekka M, Murray, Gordon J, Fordyce, Euan A. F, Prieto, Oscar, Luebbers, Thomas
Format: Article
Language:English
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Summary:Cobalt catalysis enables a new method for the generation of zinc enolates using diethylzinc to reduce α,β-unsaturated amides. This method has been applied to a high-yielding diastereoselective reductive aldol cyclization.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol061329d