Acid-base, coordination and oxidative properties of systems containing ATP, L-histidine and Ni(II) ions

Potentiometric measurements of ATP-His system proved an existence of five adducts in the solution with stoichiometries ranging from H(5)(ATP)(His) to H(ATP)(His)(4-). Their formation is a consequence of electrostatic interactions only. In the ternary Ni(II)-ATP-His system, two complex species NiH(AT...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2005-11 (22), p.3653-3657
Main Authors: Kaczmarek, Piotr, Szczepanik, Wojciech, Jezowska-Bojczuk, Małgorzata
Format: Article
Language:English
Subjects:
Acids - chemistry
Adenine - chemistry
Adenosine Triphosphate - chemistry
Cations, Divalent
DNA Adducts - chemistry
DNA Damage
DNA, Single-Stranded - chemistry
Histidine - chemistry
Hydrogen Peroxide - pharmacology
Nickel - chemistry
Oxidation-Reduction
Plasmids - chemistry
Plasmids - drug effects
Potentiometry
Static Electricity
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Summary:Potentiometric measurements of ATP-His system proved an existence of five adducts in the solution with stoichiometries ranging from H(5)(ATP)(His) to H(ATP)(His)(4-). Their formation is a consequence of electrostatic interactions only. In the ternary Ni(II)-ATP-His system, two complex species NiH(ATP)(His)(2-) and Ni(ATP)(His)(3-), were found. In the former, stacking interaction between the aromatic moiety of ATP and the imidazole ring of l-histidine is crucial to the adduct stability. All studied systems are able to generate single strand lesions of plasmid DNA in the presence of hydrogen peroxide. However, only binary systems produce linear form of DNA, which is a consequence of the accumulation of the single-stranded breaks.
ISSN:1477-9226
1477-9234
DOI:10.1039/b508962j