Anxiety- and novelty seeking-related personality traits and serotonin transporter gene polymorphisms

The affection of human personality by the promoter and the intron 2 polymorphism in the serotonin transporter gene (SERT) is inconsistently reported. We aimed to clarify this situation by gender-specific haplotype–phenotype association. 98 women and 97 men completed the personality inventories NEO-P...

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Bibliographic Details
Published in:Journal of psychiatric research 2006-09, Vol.40 (6), p.568-576
Main Authors: Vormfelde, Stefan Viktor, Hoell, Imke, Tzvetkov, Mladen, Jamrozinski, Katja, Sehrt, Daniel, Brockmöller, Jürgen, Leibing, Eric
Format: Article
Language:English
Subjects:
Adult
Anxiety
Anxiety - genetics
Anxiety - physiopathology
Biological and medical sciences
Exploratory Behavior - physiology
Female
Fundamental and applied biological sciences. Psychology
Gender
Gene Frequency
Genetics
Genotype
Human personality
Humans
Male
Minisatellite Repeats - genetics
Neuroticism
Novelty seeking
Personality
Personality Inventory
Personality traits
Personality. Affectivity
Polymorphism, Genetic
Promoter Regions, Genetic - genetics
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Serotonin
Serotonin Plasma Membrane Transport Proteins - genetics
SERT haplotypes
SERT polymorphisms
Sex Factors
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Summary:The affection of human personality by the promoter and the intron 2 polymorphism in the serotonin transporter gene (SERT) is inconsistently reported. We aimed to clarify this situation by gender-specific haplotype–phenotype association. 98 women and 97 men completed the personality inventories NEO-PI-R and TPQ. The subjects were genotyped for the two SERT polymorphisms and the haplotypes were calculated. The short (S) and long (L) promoter alleles and the 12 and 10 repeat intron 2 alleles formed the haplotypes S 12, S 10, L 12 and L 10. In men, scores in the anxiety-related dimensions were higher in S 12 than in L 12 carriers. Opposite in direction, scores tended to be lower in S 10 than in L 10 carriers. In the novelty seeking-related dimensions, scores were higher in S 10 than in S 12 carriers. No association was observed in women. In conclusion, anxiety- and novelty seeking-related personality dimensions are differentially associated with different SERT haplotypes; the consistent restriction to men suggests common androgen regulation. Opposite trends with haplotypes including the same promoter alleles suggest contribution of group stratification to earlier inconsistent findings and call to further differentiate the molecular function and clinical implications of the SERT promoter polymorphism.
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2005.10.002