Is Serum Gentamicin Level a Good Predictor of Graft Injury in Intestinal Transplantation?

• Published in: Transplantation proceedings 2006-07, Vol.38 (6), p.1733-1734
• Main Authors: Haghighi, K.S., Sharif, K., Gupte, G., Mirza, D.F., Mayer, A.D., Carroll, D., Brown, R.M., Lloyd, C., McKiernan, P.J., Baumann, U., van Mourik, I.D.M., Kelly, D.A., Beath, S.V., Millar, A.J.W.
• Format: Article
• Language: English
• Subjects: Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Biomarkers - blood; Child, Preschool; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gentamicins - blood; Graft Rejection - blood; Graft Rejection - diagnosis; Humans; Intestinal Diseases - classification; Intestinal Diseases - surgery; Intestine, Small - injuries; Intestine, Small - transplantation; Male; Medical sciences; Pharmacology. Drug treatments; Reproducibility of Results; Retrospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue, organ and graft immunology; Transplantation, Homologous - pathology
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2006.05.065

Following intestinal transplant (SBT), the early diagnosis and treatment of rejection is a major management aim. The diagnosis of rejection is based on histology of stomal biopsies. Oral gentamycin (2.5 mg/kg) was used for selective decontamination of the digestive system. Our hypothesis was that gentamycin might be absorbed in the presence of graft dysfunction. Our goal was to assess the correlation between serum gentamycin level and the health of the intestinal graft. Among 33 SBT performed from 1993 to 2005, serum gentamycin levels were performed once weekly or more often when there was a suspicion of rejection. All data were analyzed retrospectively. Adequate trough levels were achieved for only 23 patients, six of whom had histologically proven rejection and only one did not have a raised gentamycin content. Five patients with raised levels but no rejection included two with severe intestinal ischemia and three with bowel obstruction/ileus. Four of the five patients required laparotomies. We concluded that in our study raised serum gentamycin levels were a good predictor of rejection or significant injury to the graft.