High prevalence of dual or triple infection of hepatitis B, C, and delta viruses among patients with chronic liver disease in Mongolia

Mongolia is known for its high endemicity for hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis delta virus (HDV) infections among apparently healthy individuals. However, there are little or no data on the prevalence and genotype distribution of HBV, HCV, and HDV among patients with c...

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Bibliographic Details
Published in:Journal of medical virology 2005-12, Vol.77 (4), p.491-499
Main Authors: Tsatsralt-Od, Bira, Takahashi, Masaharu, Nishizawa, Tsutomu, Endo, Kazunori, Inoue, Jun, Okamoto, Hiroaki
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Hepatocellular - epidemiology
Carcinoma, Hepatocellular - etiology
Chronic Disease
dual infection
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
genotype
Hepatitis B - complications
Hepatitis B - epidemiology
Hepatitis B - immunology
Hepatitis B Antibodies - blood
Hepatitis B virus
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Hepatitis C - complications
Hepatitis C - epidemiology
Hepatitis C - immunology
Hepatitis C Antibodies - blood
Hepatitis C virus
Hepatitis D - complications
Hepatitis D - epidemiology
Hepatitis D - immunology
Hepatitis D virus
Hepatitis Delta Virus - genetics
Hepatitis Delta Virus - immunology
hepatitis viruses
Human viral diseases
Humans
Infectious diseases
Liver Neoplasms - epidemiology
Liver Neoplasms - etiology
Male
Medical sciences
Microbiology
Middle Aged
Miscellaneous
Molecular Sequence Data
Mongolia
Mongolia - epidemiology
Prevalence
triple infection
Viral diseases
Viral hepatitis
Virology
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Summary:Mongolia is known for its high endemicity for hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis delta virus (HDV) infections among apparently healthy individuals. However, there are little or no data on the prevalence and genotype distribution of HBV, HCV, and HDV among patients with chronic liver disease in Mongolia. Therefore, serum samples obtained in 2004 from 207 patients (age, mean ± standard deviation, 51.0 ± 11.9 years) including those with chronic hepatitis (n = 90), liver cirrhosis (n = 41), and hepatocellular carcinoma (n = 76) were tested for serological and molecular markers of HBV, HCV, and HDV infections. Of the 207 patients, 144 (69.6%), 106 (51.2%), and 117 (56.5%) tested positive for hepatitis B surface antigen (HBsAg) and/or HBV DNA, HCV RNA, and HDV RNA, respectively. Collectively, 172 patients (83.1%) were viremic for one or more of these viruses, including dual viremia of HBV/HDV (26.6%) or HBV/HCV (7.7%) and triple HBV/HCV/HDV viremia (30.0%). Of note, triple ongoing infection was significantly more frequent among patients with hepatocellular carcinoma than among those with chronic hepatitis (63.2% vs. 14.4%, P 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.20482