A comparative study of oxidant-antioxidant status in stable and active vitiligo patients

The pathogenetic mechanisms in vitiligo have not been completely clarified. One of the major hypotheses in the pathogenesis of vitiligo is the oxidative stress hypothesis. The active or stable phase of vitiligo is defined on the basis of the progression or appearance of new lesions in the last 3 mon...

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Bibliographic Details
Published in:Archives of Dermatological Research 2006-09, Vol.298 (4), p.147-152
Main Authors: INES, Dammak, SONIA, Boudaya, BEN MANSOUR RIADH, EL GAIED AMEL, SLAHEDDINE, Marrekchi, HAMIDA, Turki, HAMADI, Attia, BASMA, Hentati
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Catalase - blood
Dermatology
Erythrocytes - enzymology
Female
Humans
Male
Malondialdehyde - blood
Medical sciences
Middle Aged
Oxidative Stress - physiology
Peroxidase - blood
Pigmentary diseases of the skin
Selenium - blood
Severity of Illness Index
Superoxide Dismutase - blood
Vitamin A - blood
Vitamin E - blood
Vitiligo - blood
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Summary:The pathogenetic mechanisms in vitiligo have not been completely clarified. One of the major hypotheses in the pathogenesis of vitiligo is the oxidative stress hypothesis. The active or stable phase of vitiligo is defined on the basis of the progression or appearance of new lesions in the last 3 months and the absence of new lesions or their progression in the last 6 months, respectively. Eighteen patients with active vitiligo, 18 patients with stable vitiligo, and 40 controls were included in this study. We examined serum levels of malondialdehyde, selenium, vitamin E and A, and the erythrocyte activities of glutathione peroxidase, superoxide dismutase, and catalase. Our results revealed a significantly higher level of serum malondialdehyde, selenium in patients with active disease compared with the controls. Significant higher increase in erythrocytes superoxide dismutase activities was observed in active vitiligo group, erythrocyte glutathione peroxidase activity was decreased significantly in active disease, whereas erythrocyte catalase activity and plasma vitamin E and A levels were not different in vitiligo patients as compared with controls. Our study shows that oxidative stress is involved in the pathophysiology of both active and stable vitiligo but increased imbalance of antioxidants was observed in the blood of active vitiligo patients.
ISSN:0340-3696
1432-069X
DOI:10.1007/s00403-006-0680-2