The Association between Plasma Adiponectin and Insulin Sensitivity in Humans Depends on Obesity

Objective: In humans, low plasma adiponectin concentrations precede a decrease in insulin sensitivity and predict type 2 diabetes independently of obesity. However, it is possible that the contribution of adiponectin to insulin sensitivity is not equally strong over the whole range of obesity. Resea...

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Published in:Obesity (Silver Spring, Md.) Md.), 2005-10, Vol.13 (10), p.1683-1691
Main Authors: Kantartzis, Konstantinos, Fritsche, Andreas, Tschritter, Otto, Thamer, Claus, Haap, Michael, Schäfer, Silke, Stumvoll, Michael, Häring, Hans‐Ulrich, Stefan, Norbert
Format: Article
Language:English
Subjects:
adiponectin
Adiponectin - blood
adipose tissue
Adult
body fat
Cross-Sectional Studies
Female
Humans
Insulin Resistance
Male
Obesity - blood
Obesity - physiopathology
type 2 diabetes
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Summary:Objective: In humans, low plasma adiponectin concentrations precede a decrease in insulin sensitivity and predict type 2 diabetes independently of obesity. However, it is possible that the contribution of adiponectin to insulin sensitivity is not equally strong over the whole range of obesity. Research Methods and Procedures: We investigated the cross‐sectional association between plasma adiponectin levels and insulin sensitivity in different ranges of body fat content [expressed as percentage of body fat (PFAT)] in a large cohort of normal glucose‐tolerant subjects (n = 900). All individuals underwent an oral glucose tolerance test (OGTT), and 299 subjects additionally a euglycemic hyperinsulinemic clamp. In longitudinal analyses, the association of adiponectin at baseline with change in insulin sensitivity was investigated in a subgroup of 108 subjects. Results: In cross‐sectional analyses, the association between plasma adiponectin and insulin sensitivity, adjusted for age, gender, and PFAT, depended on whether subjects were lean or obese [p for interaction adiponectin × PFAT =
ISSN:1930-7381
1071-7323
1930-739X
1550-8528
DOI:10.1038/oby.2005.206