Oncogenic β-Catenin Signaling Networks in Colorectal Cancer

β-catenin has two distinct functions, namely, maintaining cell-to-cell adhesion and mediating the Wnt/β-catenin signal transduction pathway, which plays pivotal roles in embryogenesis and in malignant transformation of cells. The oncogenic properties of Wnt/β-catenin signaling stem from alteration i...

Full description

Saved in:
Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2005-11, Vol.4 (11), p.1522-1539
Main Authors: Fuchs, Serge Y, Ougolkov, Andrei V, Spiegelman, Vladimir S, Minamoto, Toshinari
Format: Article
Language:English
Subjects:
Animals
beta Catenin - metabolism
beta Catenin - physiology
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Colorectal Neoplasms - chemistry
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Cycle
Humans
Landes
Oncogene Proteins - metabolism
Oncogene Proteins - physiology
Organogenesis
Proteins
Signal Transduction - physiology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:β-catenin has two distinct functions, namely, maintaining cell-to-cell adhesion and mediating the Wnt/β-catenin signal transduction pathway, which plays pivotal roles in embryogenesis and in malignant transformation of cells. The oncogenic properties of Wnt/β-catenin signaling stem from alteration in phosphorylation-dependent protein degradation and subcellular localization of β-catenin from cell membrane to the nucleus, where it binds to T-cell factor (Tcf) to form a bipartite transcription factor. The β-catenin/Tcf complex facilitates transcription of target genes that encode effectors for activation of cell proliferation and invasion and inhibition of apoptosis, leading to colorectal cancer development. In addition, in the tumor invasion front, stabilized and activated β-catenin interacts with other molecular pathways to facilitate tumor progression. This review highlights the β-catenin-dependent oncogenic signaling network involved in the multi-step process of colorectal tumorigenesis. Wnt signaling evidently regulates stem cells, leading them to differentiate or self-renew. We address roles of oncogenic β-catenin signaling in the microenvironment of the tumor-host interface that determine the individual tumor's malignant potential and in regulation of putative cancer stem or progenitor cells that represent plausible targets for cancer eradication.
ISSN:1538-4101
1551-4005
DOI:10.4161/cc.4.11.2129