Membrane curvature and mechanisms of dynamic cell membrane remodelling

Membrane curvature is no longer seen as a passive consequence of cellular activity but an active means to create membrane domains and to organize centres for membrane trafficking. Curvature can be dynamically modulated by changes in lipid composition, the oligomerization of curvature scaffolding pro...

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Bibliographic Details
Published in:Nature 2005-12, Vol.438 (7068), p.590-596
Main Authors: McMahon, Harvey T, Gallop, Jennifer L
Format: Article
Language:English
Subjects:
Cell Membrane - chemistry
Cell Membrane - metabolism
Cellular biology
Cytoskeleton - metabolism
Humanities and Social Sciences
Membrane Lipids - metabolism
Membrane Proteins - chemistry
Membrane Proteins - metabolism
Membranes
Microenvironments
Microtubules - metabolism
Molecular Motor Proteins - metabolism
multidisciplinary
Proteins
review-article
Science
Science (multidisciplinary)
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Summary:Membrane curvature is no longer seen as a passive consequence of cellular activity but an active means to create membrane domains and to organize centres for membrane trafficking. Curvature can be dynamically modulated by changes in lipid composition, the oligomerization of curvature scaffolding proteins and the reversible insertion of protein regions that act like wedges in membranes. There is an interplay between curvature-generating and curvature-sensing proteins during vesicle budding. This is seen during vesicle budding and in the formation of microenvironments. On a larger scale, membrane curvature is a prime player in growth, division and movement.
ISSN:0028-0836
1476-4687
1476-4679
DOI:10.1038/nature04396