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Alu elements within human mRNAs are probable microRNA targets

Recently, we reported that four microRNAs show perfect complementarity with MIR/LINE-2 elements within human mRNAs. This finding raises the question of whether microRNAs might also target other genomic repeats and transposable elements. Here, we demonstrate that almost 30 human microRNAs exhibit typ...

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Published in:	Trends in genetics 2006-10, Vol.22 (10), p.532-536
Main Authors:	Smalheiser, Neil R., Torvik, Vetle I.
Format:	Article
Language:	English
Subjects:	3' Untranslated Regions Alu Elements Base Sequence Biological and medical sciences Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genic rearrangement. Recombination. Transposable element Humans MicroRNAs - genetics MicroRNAs - metabolism Models, Genetic Molecular and cellular biology Molecular genetics Molecular Sequence Data RNA, Messenger - chemistry Sequence Alignment
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container_title	Trends in genetics
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creator	Smalheiser, Neil R. Torvik, Vetle I.
description	Recently, we reported that four microRNAs show perfect complementarity with MIR/LINE-2 elements within human mRNAs. This finding raises the question of whether microRNAs might also target other genomic repeats and transposable elements. Here, we demonstrate that almost 30 human microRNAs exhibit typical short-seed complementarity with a specific site within Alu elements that is highly conserved within 3′ untranslated regions of human mRNAs. The results suggest that at least some Alu elements within human mRNAs serve as microRNA targets.
doi_str_mv	10.1016/j.tig.2006.08.007
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subjects	3' Untranslated Regions Alu Elements Base Sequence Biological and medical sciences Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Genic rearrangement. Recombination. Transposable element Humans MicroRNAs - genetics MicroRNAs - metabolism Models, Genetic Molecular and cellular biology Molecular genetics Molecular Sequence Data RNA, Messenger - chemistry Sequence Alignment
title	Alu elements within human mRNAs are probable microRNA targets
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